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Treatments for Convulsive and Nonconvulsive Status Epilepticus in Adults: An Expert Opinion Survey in South Korea

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Author(s)
Jung-Ick ByunDong Wook KimKeun Tae KimKwang Ik YangSoon-Tae LeeJong-Geun SeoYoung Joo NoKyung Wook KangDaeyoung KimYong Won ChoJae-Moon Kim
Keimyung Author(s)
Kim, Keun TaeCho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of Clinical Neurology
Issued Date
2021
Volume
17
Issue
1
Keyword
consensustreatmentstatus epilepticusnonconvulsive status epilepticus
Abstract
Background and Purpose:
The aim of this study was to survey the expert opinions on treatments for convulsive status epilepticus (CSE) and nonconvulsive status epilepticus (NCSE) in adults.

Methods:
Forty-two South Korean epileptologists participated in this survey. They completed an online questionnaire regarding various patient scenarios and evaluated the appropriateness of medications used to treat CSE and NCSE.

Results:
Initial treatment with a benzodiazepine (BZD) followed by either a second BZD or an antiepileptic drug (AED) monotherapy was the preferred treatment strategy. More than two-thirds of the experts used a second BZD when the first one failed, and consensus was reached for 84.8% of the survey items. The preferred BZD was intravenous (IV) lorazepam for the initial treatment of status epilepticus. IV fosphenytoin and IV levetiracetam were chosen for AED monotherapy after the failure of BZD. The treatments for NCSE were similar to those for CSE. Continuous IV midazolam infusion was the treatment of choice for iatrogenic coma in refractory CSE, but other AEDs were preferred over iatrogenic coma in refractory NCSE.

Conclusions:
The results of this survey are consistent with previous guidelines, and can be cautiously applied in clinical practice when treating patients with CSE or NCSE.
Keimyung Author(s)(Kor)
김근태
조용원
Publisher
School of Medicine (의과대학)
Citation
Jung-Ick Byun et al. (2021). Treatments for Convulsive and Nonconvulsive Status Epilepticus in Adults: An Expert Opinion Survey in South Korea. Journal of Clinical Neurology, 17(1), 20–25. doi: 10.3988/jcn.2021.17.1.20
Type
Article
ISSN
2005-5013
Source
https://www.thejcn.com/search.php?where=aview&id=10.3988/jcn.2021.17.1.20&code=0145JCN&vmode=FULL
DOI
10.3988/jcn.2021.17.1.20
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43350
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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