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Causes of necrotic features in fine-needle aspirates from cervical lymph nodes

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Author(s)
Young Jin SeoHyeongchan ShinHye Won LeeHye Ra Jung
Keimyung Author(s)
Shin, Hyeong ChanLee, Hye WonJung, Hye Ra
Department
Dept. of Pathology (병리학)
Journal Title
Journal of Pathology and Translational Medicine
Issued Date
2021
Volume
55
Issue
1
Keyword
Fine-needle aspirationLymph nodeNecrosisTuberculosisKikuchi disease
Abstract
Background:
Lymph node fine-needle aspiration (LN FNA) cytology indicates necrosis in various diseases. Dominant necrotic features make the diagnosis of underlying conditions very difficult.

Methods:
We retrospectively reviewed 460 patients who underwent cervical LN aspiration cytology that revealed necrotic findings at Keimyung University Dongsan Hospital in Daegu, Korea, from 2003–2017. Each specimen was evaluated and analyzed in association with the clinical findings, biopsy findings, and/or other ancillary tests, including acid-fast bacilli staining and molecular testing for Mycobacterium tuberculosis.

Results:
When necrotic features were noted upon cervical LN FNA cytology, the most common pathologic LN FNA category was necrosis alone (31.5%). The second most common category was granulomatous inflammation (31.3%), followed by Kikuchi disease (20.0%) and malignant neoplasm (8.7%). In cases where the cervical LN FNA revealed necrosis alone, the most common final diagnosis was tuberculosis. In young patients, Kikuchi disease should be considered as one cervical LN FNA category, while metastatic carcinoma should be suspected in older patients.

Conclusions:
Even when necrosis alone is observed in LN FNA cytology, it is important to determine the cause through further evaluation.
Keimyung Author(s)(Kor)
신형찬
이혜원
정혜라
Publisher
School of Medicine (의과대학)
Citation
Young Jin Seo et al. (2021). Causes of necrotic features in fine-needle aspirates from cervical lymph nodes. Journal of Pathology and Translational Medicine, 55(1), 60–67. doi: 10.4132/jptm.2020.09.28
Type
Article
ISSN
2383-7845
Source
https://www.jpatholtm.org/journal/view.php?number=16941
DOI
10.4132/jptm.2020.09.28
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43354
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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