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Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970

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Author(s)
Bon San KooHye-Jin JeongChang-Nam SonSang-Hyon KimHyun Jung KimGheun-Ho KimJae-Bum Jun
Alternative Author(s)
Jeong, Hye-JinSon, Chang NamKim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
The Korean Journal of Internal Medicine
Issued Date
2021
Volume
36
Number
Suppl 1
Keyword
HyperuricemiaHypouricemiaPopulationPrevalenceUric acid
Abstract
Background/Aims:
We investigated the distribution of serum uric acid (SUA) levels and estimated the prevalence of hyperuricemia and hypouricemia in the Korean population.

Methods:
This cross-sectional study used data from the Korean Genome and Epidemiology Study and included 172,970 participants (58,981 men and 113,989 women) aged 40 to 79 years. Hypouricemia and hyperuricemia were defined as SUA level ≤ 2.0 mg/dL and > 7 mg/dL, respectively. The prevalence of hyperuricemia and hypouricemia was evaluated by age and sex.

Results:
The mean SUA levels were significantly higher in men than in women (5.71 ± 1.27 mg/dL vs. 4.21 ± 0.96 mg/dL, p < 0.001). The mean SUA levels and prevalence of hyperuricemia increased with age in women but not in men. The overall prevalence of hyperuricemia and that in men and women was 50.82, 133.25, and 8.17 per 1,000 persons, respectively; the overall prevalence of hypouricemia and that in men and women was 4.16, 1.10, and 5.75 per 1,000 persons, respectively. The prevalence of hypouricemia in men was similar across all age groups; however, that in women was the highest in the age group of 40 to 49 years and the lowest in the age group of 50 to 59 years.

Conclusions:
The distribution of SUA levels and prevalence of hyperuricemia and hypouricemia differed according to age and sex. Age and sex should be considered in studies on uric acid-related diseases.
Affiliated Author(s)
정혜진
손창남
김상현
Publisher
School of Medicine (의과대학)
Citation
Bon San Koo et al. (2021). Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970. The Korean Journal of Internal Medicine, 36(Suppl 1), S264–S272. doi: 10.3904/kjim.2020.116
Type
Article
ISSN
2005-6648
Fulltext
https://www.kjim.org/journal/view.php?number=170514
DOI
10.3904/kjim.2020.116
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43364
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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