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Efficacy and Safety of Dual-Drug-Eluting Stents for de Novo Coronary Lesions in South Korea-The Effect Trial

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Author(s)
Jung-Joon ChaGi Chang KimSeung Ho HurJang Ho BaeJae Woong ChoiDong-Kyu JinSeong Il WooSeung Uk LeeJong Seon ParkYun-Hyeong ChoCheol Ung ChoiDo-Sun LimTae Hoon Ahn
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Clinical Medicine
Issued Date
2021
Volume
10
Issue
1
Keyword
dual drug-eluting stentCilotax™ stentDXR™ stentcoronary artery diseaseclinical outcome
Abstract
Background: Drug-eluting stents (DESs) are commonly used in percutaneous coronary intervention (PCI) procedures; however, complications including in-stent restenosis and stent thrombosis are significant challenges. The dual-DES is a stent that elutes two drugs to target various stages of the restenosis reaction. This study investigated the safety and efficacy of dual-DES in clinical practice. Methods: This study included 375 patients who underwent PCI with Cilotax™ or DXR™ dual-DESs at one of 13 centers in South Korea. The primary endpoint was target lesion failure (TLF) within 1 year. The secondary endpoints were cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), and stent thrombosis. Results: The rates of TLF in dual-DESs (3.7%) were comparable to those reported in conventional DES. In addition, the DXR™ group had a significantly lower rate of TLF than the Cilotax™ group. In multivariate analysis, the DXR™ group had a lower risk of TLF (adjusted hazard ratio (HR) 0.30, 95% CI 0.09–0.92, p = 0.036) and MI (adjusted HR 0.16, 95% CI 0.03–0.82, p = 0.027) than the Cilotax™ group. Conclusion: Dual-DESs had similar clinical outcomes regarding efficacy and safety as conventional DES. Among the dual-DES, the DXR™ stent as a new generation dual-DES had more favorable clinical outcomes than the Cilotax™ stent.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Citation
Jung-Joon Cha et al. (2021). Efficacy and Safety of Dual-Drug-Eluting Stents for de Novo Coronary Lesions in South Korea-The Effect Trial. Journal of Clinical Medicine, 10(1), 69. doi: 10.3390/jcm10010069
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/10/1/69
DOI
10.3390/jcm10010069
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43456
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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