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Association of Postural Instability with Autonomic Dysfunction in Early Parkinson's Disease

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Author(s)
Sooyeoun YouHyun Ah KimHyung Lee
Keimyung Author(s)
You, Soo YeounKim, Hyun AhLee, Hyung
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of Clinical Medicine
Issued Date
2020
Volume
9
Issue
11
Keyword
Parkinson's diseaseposturographyautonomic function testheart rate variabilitycorrelationparasympathetic activity
Abstract
Background: There have been several pathologic data that support an association between postural instability (PI) and autonomic dysfunction in Parkinson's disease (PD). The purpose of this study was to investigate the correlation of PI and autonomic deficits in early PD. Methods: We collected 17 patients with a diagnosis of early PD. PI was assessed by computerized dynamic posturography (CDP). Standardized autonomic function test (AFT) and time and frequency domain spectral analysis of heart rate variability (HRV) were performed. CDP data obtained from the 21 patients were compared to that from age- and sex-matched healthy controls. We collected HRV data from 18 other age- and sex-matched controls. All patients were evaluated in the "OFF" state. We used Mann–Whitney U-test to compare parameters of CDP between the early PD and control groups. Spearman correlation was used for correlation analysis between parameters of CDP and autonomic function test in PD patients. Results: Most patients (76.5%) showed mild or moderate autonomic dysfunction in the standardized AFT. In CDP, sensory ratios of equilibrium score (e.g., visual and vestibular) and composite scores were significantly lower in PD patients than in controls. In HRV, the low-frequency/high-frequency ratio during the tilt and the gap of low- frequency/high-frequency ratio from supine to tilt were significantly different in both groups. The parameters of time and frequency domains of HRV reflecting parasympathetic function were correlated with equilibrium scores for somatosensory organization test in CDP. Discussion: PI was associated with parasympathetic autonomic dysfunction in early PD. This result was in accordance with a previous assumption that PI in PD is related to parasympathetic cholinergic neuron loss in the brainstem.
Keimyung Author(s)(Kor)
유수연
김현아
이형
Publisher
School of Medicine (의과대학)
Citation
Sooyeoun You et al. (2020). Association of Postural Instability with Autonomic Dysfunction in Early Parkinson’s Disease. Journal of Clinical Medicine, 9(11), 3786. doi: 10.3390/jcm9113786
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/9/11/3786
DOI
10.3390/jcm9113786
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43459
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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