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Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry

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Author(s)
Myunhee LeeDae-Won KimMahn-Won ParkKyusup LeeKiyuk ChangWook Sung ChungTae Hoon AhnMyung Ho JeongSeung-Woon RhaHyo-Soo KimHyeon Cheol GwonIn Whan SeongKyung Kuk HwangShung Chull ChaeKwon-Bae KimYoung Jo KimKwang Soo ChaSeok Kyu OhJei Keon ChaeJi-Hoon Jung
Keimyung Author(s)
Kim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Geriatric Cardiology
Issued Date
2020
Volume
17
Issue
11
Keyword
Acute myocardial infarctionAsian populationGender differencePercutaneous coronary intervention
Abstract
Background:
There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention (PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction (AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials.

Methods:
A total of 13, 104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015 were classified into male (n = 8021, 75.9%) and female (n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events (MACCE) in women with those in men after AMI by using propensity score (PS) matching.

Results:
Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction (NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population (30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585; 1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328; TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P= 0.215, HR = 1.255, 95% CI: 0.869-1.814).

Conclusions:
Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.
Keimyung Author(s)(Kor)
김권배
Publisher
School of Medicine (의과대학)
Citation
Myunhee Lee et al. (2020). Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry. Journal of Geriatric Cardiology, 17(11), 680–693. doi: 10.11909/j.issn.1671-5411.2020.11.006
Type
Article
ISSN
1671-5411
Source
http://www.jgc301.com/en/article/doi/10.11909/j.issn.1671-5411.2020.11.006
DOI
10.11909/j.issn.1671-5411.2020.11.006
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43460
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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