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Stress Myocardial Perfusion Imaging vs Coronary Computed Tomographic Angiography for Diagnosis of Invasive Vessel-Specific Coronary Physiology: Predictive Modeling Results From the Computed Tomographic Evaluation of Atherosclerotic Determinants of Myocardial Ischemia (CREDENCE) Trial

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Author(s)
Wijnand J. StuijfzandAlexander R. van RosendaelFay Y. LinHyuk-Jae ChangInge J. van den HoogenUmberto GianniJung Hyun ChoiJoon-Hyung DohAe-Young HerBon-Kwon KooChang-Wook NamHyung-Bok ParkSang-Hoon ShinJason ColeAlessia GimelliMuhammad Akram KhanBin LuYang GaoFaisal NabiRyo NakazatoU. Joseph SchoepfRoel S. DriessenMichiel J. BomRandall ThompsonJames J. JangMichael RidnerChris RowanErick AvelarPhilippe GénéreuxPaul KnaapenGuus A. de WaardGianluca PontoneDaniele AndreiniMouaz H. Al-MallahYao LuDaniel S. BermanJagat NarulaJames K. MinJeroen J. BaxLeslee J. Shaw
Keimyung Author(s)
Nam, Chang Wook
Department
Dept. of Internal Medicine (내과학)
Journal Title
JAMA cardiology
Issued Date
2020
Volume
5
Issue
12
Abstract
Importance:
Stress imaging has been the standard for diagnosing functionally significant coronary artery disease. It is unknown whether novel, atherosclerotic plaque measures improve accuracy beyond coronary stenosis for diagnosing invasive fractional flow reserve (FFR) measurement.

Objective:
To compare the diagnostic accuracy of comprehensive anatomic (obstructive and nonobstructive atherosclerotic plaque) vs functional imaging measures for estimating vessel-specific FFR.

Design, Setting, and Participants:
Controlled clinical trial of diagnostic accuracy with a multicenter derivation-validation cohort of patients referred for nonemergent invasive coronary angiography. A total of 612 patients (64 [10] years; 30% women) with signs and symptoms suggestive of myocardial ischemia from 23 sites were included. Patients were recruited from 2014 to 2017. Data analysis began in August 2018.

Interventions:
Patients underwent invasive coronary angiography with measurement of invasive FFR, coronary computed tomographic angiography (CCTA) quantification of atherosclerotic plaque and FFR by CT (FFR-CT), and semiquantitative scoring of rest/stress myocardial perfusion imaging (by magnetic resonance, positron emission tomography, or single photon emission CT). Multivariable generalized linear mixed models were derived and validated calculating the area under the receiver operating characteristics curve.

Main Outcomes and Measures:
The primary end point was invasive FFR of 0.80 or less.

Results:
Of the 612 patients, the mean (SD) age was 64 (10) years, and 426 (69.9%) were men. An invasive FFR of 0.80 or less was measured in 26.5% of 1727 vessels. In the derivation cohort, CCTA vessel-specific factors associated with FFR 0.80 or less were stenosis severity, percentage of noncalcified atheroma volume, lumen volume, the number of lesions with high-risk plaque (≥2 of low attenuation plaque, positive remodeling, napkin ring sign, or spotty calcification), and the number of lesions with stenosis greater than 30%. Fractional flow reserve–CT was not additive to this model including stenosis and atherosclerotic plaque. Significant myocardial perfusion imaging predictors were the summed rest and difference scores. In the validation cohort, the areas under the receiver operating characteristic curve were 0.81 for CCTA vs 0.67 for myocardial perfusion imaging (P < .001).

Conclusions and Relevance:
A comprehensive anatomic interpretation with CCTA, including quantification of obstructive and nonobstructive atherosclerotic plaque, was superior to functional imaging in the diagnosis of invasive FFR. Comprehensive CCTA measures improve prediction of vessel-specific coronary physiology more so than stress-induced alterations in myocardial perfusion.
Keimyung Author(s)(Kor)
남창욱
Publisher
School of Medicine (의과대학)
Citation
Wijnand J. Stuijfzand et al. (2020). Stress Myocardial Perfusion Imaging vs Coronary Computed Tomographic Angiography for Diagnosis of Invasive Vessel-Specific Coronary Physiology: Predictive Modeling Results From the Computed Tomographic Evaluation of Atherosclerotic Determinants of Myocardial Ischemia (CREDENCE) Trial. JAMA cardiology, 5(12), 1338–1348. doi: 10.1001/jamacardio.2020.3409
Type
Article
ISSN
2380-6591
Source
https://jamanetwork.com/journals/jamacardiology/article-abstract/2769554
DOI
10.1001/jamacardio.2020.3409
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43467
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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