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Two-year outcomes of the treat-and-extend regimen using aflibercept for treating diabetic macular oedema

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Author(s)
Yu Cheol KimJae Pil ShinKang Yeun PakHyun Woong KimMin SagongSang Joon LeeIn Young ChungSung Who ParkJi Eun Lee
Keimyung Author(s)
Kim, Yu Cheol
Department
Dept. of Ophthalmology (안과학)
Journal Title
Scientific Reports
Issued Date
2020
Volume
10
Abstract
This study was performed to investigate the efficacy of the treat-and-extend regimen using aflibercept for treating diabetic macular oedema (DME). This prospective, multicentre, interventional, single-arm, 104-week clinical trial included 48 patients with DME visual impairment. The patients' eyes received five consecutive intravitreal injections (2 mg aflibercept) every four weeks with two-week adjustments based on central subfield macular thickness (CSMT) changes. Injections were deferred when CSMT was stable. The number of injections, best-corrected visual acuity (BCVA), CSMT, and diabetic retinopathy severity scale scores were analysed. Compared to baseline, BCVA improved by + 9.1 letters at 52 weeks and was maintained with + 9.4-letter gain at 104 weeks (P < 0.001). Between baseline and 104 weeks, CSMT decreased from 489 to 298 μm (P < 0.001) and eyes with vision ≥ 20/40 increased from 17.4 to 43.5% (P = 0.007). The mean number of injections decreased from 8.5 in year one to 3.9 in year two. The injection interval was extended to ≥ 12 weeks in 56.5% of patients. The treat-and-extend regimen of aflibercept in DME showed 2-year efficacy comparable to that of fixed dosing regimens. The flexible dosing of this regimen reduced the number of injections in year two while maintaining efficacy.
Keimyung Author(s)(Kor)
김유철
Publisher
School of Medicine (의과대학)
Citation
Yu Cheol Kim et al. (2020). Two-year outcomes of the treat-and-extend regimen using aflibercept for treating diabetic macular oedema. Scientific Reports, 10, 22030. doi: 10.1038/s41598-020-78954-3
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-020-78954-3
DOI
10.1038/s41598-020-78954-3
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43489
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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