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Survival rate dependent variations in retinopathy of prematurity treatment rates in very low birth weight infants

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Author(s)
Jae Hyun ParkJong Hee HwangYun Sil ChangMyung Hee LeeWon Soon Park
Keimyung Author(s)
Park, Jae Hyun
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Scientific Reports
Issued Date
2020
Volume
10
Abstract
As increased oxidative stress causes increased mortality and morbidities like bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) in very low birth weight infants (VLBWIs), the conundrum of improved survival but increased ROP observed with the high oxygen saturation target range of 91–95% is difficult to explain. To determine the survival rate-dependent variation in ROP treatment rate, 6292 surviving eligible VLBWIs registered in the Korean Neonatal Network were arbitrarily grouped according to the survival rate of infants at 23–24 weeks' gestation as group I (> 70%, n = 1626), group II (40–70%, n = 2984) and group III (< 40%, n = 1682). Despite significantly higher survival and lower BPD rates in group I than in groups II and III, the ROP treatment rate was higher in group I than in groups II and III. However, the adjusted odds ratios for ROP treatment were not significantly different between the study groups, and the ROP treatment rate in the infants at 23–24 weeks' gestation was 21-fold higher than the infants at ≥ 27 weeks' gestation. The controversial association between improved survival and reduced BPD reflecting quality improvement of neonatal intensive care but increased ROP treatment rate might be primarily attributed to the improved survival of the most immature infants.
Keimyung Author(s)(Kor)
박재현
Publisher
School of Medicine (의과대학)
Citation
Jae Hyun Park et al. (2020). Survival rate dependent variations in retinopathy of prematurity treatment rates in very low birth weight infants. Scientific Reports, 10, 19401. doi: 10.1038/s41598-020-76472-w
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-020-76472-w
DOI
10.1038/s41598-020-76472-w
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43490
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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