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Molecular heterogeneity in intrahepatic cholangiocarcinoma

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Author(s)
Keun Soo AhnKoo Jeong Kang
Keimyung Author(s)
Ahn, Keun SooKang, Koo Jeong
Department
Dept. of Surgery (외과학)
Journal Title
World Journal of Hepatology
Issued Date
2020
Volume
12
Issue
12
Keyword
CholangiocarcinomaMutationGene expressionPathwayTarget therapyMolecular
Abstract
Intrahepatic cholangiocarcinoma (iCCA) is a heterogeneous primary liver cancer, and currently there exist only a few options of targeted therapy. Histopathologically, iCCA is sub-classified according to morphology (mass forming type, periductal infiltrating type, and intraductal growing type) and histology (small duct type and large duct type). According to different histopathological types, clinical features such as risk factors and prognosis vary. Recent developments in genomic profiling have revealed several molecular markers for poor prognosis and activation of oncogenic pathways. Exploration of molecular characteristics of iCCA in each patient is a major challenge in a clinical setting, and there is no effective molecular-based targeted therapy. However, several recent studies suggested molecular-based subtypes with corresponding clinical and pathological features. Even though the subtypes have not yet been validated, it is possible that molecular features can be predicted based on clinicopathological characteristics and that this could be used for a more rational approach to integrative clinical and molecular subclassification and targeted therapy. In this review, we explored the genomic landscape of iCCA and attempted to find relevance between clinicopathologic and molecular features in molecular subtypes in several published studies. The results reveal future directions that may lead to a rational approach to the targeted therapy.
Keimyung Author(s)(Kor)
안근수
강구정
Publisher
School of Medicine (의과대학)
Citation
Keun Soo Ahn and Koo Jeong Kang. (2020). Molecular heterogeneity in intrahepatic cholangiocarcinoma. World Journal of Hepatology, 12(12), 1148–1157. doi: 10.4254/wjh.v12.i12.1148
Type
Article
ISSN
1948-5182
Source
https://www.wjgnet.com/1948-5182/full/v12/i12/1148.htm
DOI
10.4254/wjh.v12.i12.1148
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43495
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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