Clinically Significant Monocyte Biomarker for Differential Diagnosis of COVID-19 Pneumonia in the Emergency Department
- Author(s)
- 김효원; 전재천; 최우익; 이지연; 권용식; 이미진; 조재완; 김균무; 문유호; 이상훈
- Keimyung Author(s)
- Jeon, Jae Cheon; Choi, Woo Ik; Lee, Ji Yeon; Kwon, Yong Shik; Lee, Sang Hun
- Department
- Dept. of Emergency Medicine (응급의학)
Dept. of Internal Medicine (내과학)
- Journal Title
- Keimyung Med J
- Issued Date
- 2021
- Volume
- 40
- Issue
- 1
- Keyword
- COVID-19; Emergencies; Monocytes; Pneumonia
- Abstract
- To determine basic patient characteristics and biomarkers to help in the early diagnosis of Coronavirus disease 2019 (COVID-19) pneumonia in patients with pneumonia who visited the emergency department (ED). This retrospective study evaluated patients diagnosed with community-acquired pneumonia (CAP) or COVID-19 pneumonia in the ED at four tertiary medical centers between February 1 and March 31, 2020. Parameters related to the differential diagnosis between CAP and COVID-19 were investigated. Clinical characteristics and laboratory results of biomarkers were analyzed. In total, 81 patients presented to the ED with COVID-19 pneumonia. Multivariate logistic regression analysis showed that monocyte count [odds ratio (OR): 0.996; 95% confidence interval (CI): 0.994–0.999] and pneumonia severity index (PSI) [OR: 1.025; 95% CI: 1.002–1.049] were associated with diagnosis of COVID-19 pneumonia. The area under the curve comprising the combination of monocyte and PSI was 0.789. Differential diagnosis of COVID-19 pneumonia from pneumonia patients who visited the ED can be made by monocyte count and PSI score.
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