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BALAD and BALAD-2 predict survival of hepatocellular carcinoma patients: a North American cohort study

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Author(s)
Nicha WongjarupongGabriela M. Negron-OcasioKristin C. MaraKritika PrasaiMohamed A. AbdallahKeun Soo AhnJu Dong YangBenyam D. AddissieNasra H. GiamaWilliam S. HarmsenTerry M. TherneauLewis R. Roberts
Keimyung Author(s)
Ahn, Keun Soo
Department
Dept. of Surgery (외과학)
Journal Title
HPB : the official journal of the International Hepato Pancreato Biliary Association
Issued Date
2021
Volume
23
Issue
5
Abstract
Background:
The BALAD score and BALAD-2 class derived from bilirubin, albumin, AFP, AFP-L3, and des-gamma-carboxyprothrombin (DCP) are effective in predicting mortality in HCC, but have not been validated in North America.

Methods:
148 HCC patients from 2000 to 2015 who had all five biomarkers tested at diagnosis were included. Hazard ratios (HR) were calculated.

Results:
75 patients died during a median follow-up of 21.9 months. 1-and 3-year survival rates were 70.8% and 47.6%. 114 (77%) had cirrhosis. The HR (95%CI) for death were 1.24 (0.42-3.67), 1.79 (0.61-5.26), 2.83 (0.95-8.38), and 7.19 (2.26-22.91) for BALAD scores 1, 2, 3, and 4 vs. BALAD 0. The HR (95%CI) for death were 1.25 (0.65-2.40), 1.75 (0.94-3.23), and 6.20 (3.29-11.68) for BALAD-2 classes 2, 3, and 4 vs. BALAD-2 class 1. A multivariate model incorporating maximal tumor diameter, tumor number, neutrophil-lymphocyte ratio, and BALAD had HR of 1.43 (1.14-1.81) per increase of 1 BALAD score. A similar model with BALAD-2 had HR of 1.50 (1.18-1.90) per increase of 1 BALAD-2 class.

Conclusion:
BALAD models at diagnosis can predict the survival of HCC patients in North America. AFP, AFP-L3, and DCP reflect tumor progression and metastasis of HCC and distinguish the BALAD model from other predictive models.
Keimyung Author(s)(Kor)
안근수
Publisher
School of Medicine (의과대학)
Citation
Nicha Wongjarupong et al. (2021). BALAD and BALAD-2 predict survival of hepatocellular carcinoma patients: a North American cohort study. HPB : the official journal of the International Hepato Pancreato Biliary Association, 23(5), 762–769. doi: 10.1016/j.hpb.2020.09.014
Type
Article
ISSN
1477-2574
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1365182X2031159X
DOI
10.1016/j.hpb.2020.09.014
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43549
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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