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Appropriate Number of Adjuvant Chemotherapy Cycles for Patients with Stage 2 or 3 Gastric Cancer After Curative Gastrectomy: A Multicenter Cohort Study

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Author(s)
Sang-Ho JeongMoon-Won YooYoung-Gil SonSung Jin OhJong-Han KimHyoung-Il KimJoong-Min ParkHoon HurYe Seob JeeSun-Hwi HwangSung-Ho JinSang Eok LeeYong-Joon LeeKyung Won SeoSungsoo ParkChang Min LeeChang Hyun KimIn Ho JeongHan Hong LeeSung Il ChoiSang-Il LeeChan Young KimHyundong ChaeMyoung-Won SonKyung Ho PakSungsoo KimMoon-Soo LeeJae-Seok Min -Show
Keimyung Author(s)
Son, Young Gil
Department
Dept. of Surgery (외과학)
Journal Title
Ann Surg Oncol
Issued Date
2021
Volume
28
Abstract
Background:
Few studies have presented evidence pertaining to the adequate minimum number of adjuvant chemotherapy (AC) cycles required to achieve an oncologic benefit for gastric cancer.

Methods:
From January 2012 to December 2013, data from patients who underwent curative radical gastrectomy and consequently received AC for pathologic stage 2 or 3 gastric cancer at 27 institutions in South Korea were analyzed.

Results:
The study enrolled 925 patients, 661 patients (71.5%) who completed 8 cycles of AC and 264 patients (28.5%) who did not. Compared with the mean disease-free survival (DFS) of the patients who completed 8 AC cycles (69.3 months), the mean DFS of patients who completed 6 AC cycles (72.4 months; p = 0.531) and those who completed 7 AC cycles (63.7 months; p = 0.184) did not differ significantly. However, the mean DFS of the patients who completed 5 AC cycles (48.2 months; p = 0.016) and those who completed 1–4 AC cycles (62.9 months; p = 0.036) was significantly lower than the DFS of those who completed 8 AC cycles. In the multivariate Cox proportional hazards analysis, the mean DFS was significantly affected by advanced stage, large tumor size, positive vascular invasion, and number of completed AC cycles (1–5 cycles: hazard ratio 1.45; 95% confidence interval 1.01–2.08; p = 0.041).

Conclusion:
The current multicenter observational cohort study showed that the mean DFS for 6 or 7 AC cycles was similar to that for 8 AC cycles as an adjuvant treatment for gastric cancer.
Keimyung Author(s)(Kor)
손영길
Publisher
School of Medicine (의과대학)
Citation
Sang-Ho Jeong et al. (2021). Appropriate Number of Adjuvant Chemotherapy Cycles for Patients with Stage 2 or 3 Gastric Cancer After Curative Gastrectomy: A Multicenter Cohort Study. Ann Surg Oncol, 28, 4458–4470. doi: 10.1245/s10434-020-09504-4
Type
Article
ISSN
1534-4681
Source
https://link.springer.com/article/10.1245%2Fs10434-020-09504-4
DOI
10.1245/s10434-020-09504-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43568
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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