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Fluoroquinolone Can Be an Effective Treatment Option for Acute Pyelonephritis When the Minimum Inhibitory Concentration of Levofloxacin for the Causative Escherichia coli Is ≤16 mg/L

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Author(s)
Yeonjae KimBongyoung KimSeong Heon WieJieun KimMoran KiYong Kyun ChoSeung Kwan LimJin Seo LeeKi Tae KwonHyuck LeeHee Jin CheongDae Won ParkSeong Yeol RyuMoon Hyun ChungHyunjoo Pai
Keimyung Author(s)
Ryu, Seong Yeol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Antibiotics
Issued Date
2021
Volume
10
Issue
1
Keyword
urinary tract infectionpyelonephritisE. colifluoroquinolonetreatment
Abstract
The purpose of this study was to determine whether the fluoroquinolone (FQ) minimum inhibitory concentration (MIC) for the causative agent Escherichia coli influences the clinical response of FQ treatment at 72 h in patients with community-acquired acute pyelonephritis (CA-APN). We prospectively collected the clinical data of women with CA-APN from 11 university hospitals from March 2010 to February 2012 as well as E. coli isolates from the urine or blood. In total, 78 patients included in this study received FQ during the initial 72 h, and the causative E. coli was detected. The clinical response at 72 h was significantly higher in patients with a levofloxacin MIC ≤ 16 mg/L than in those with an MIC > 16 mg/L (70.4% vs. 28.6%, p = 0.038). No difference was observed in clinical response at 72 h based on ciprofloxacin MIC. To summarize, FQ can be an effective treatment option for CA-APN when levofloxacin MIC against E. coli is ≤16 mg/L.
Keimyung Author(s)(Kor)
류성열
Publisher
School of Medicine (의과대학)
Citation
Yeonjae Kim et al. (2021). Fluoroquinolone Can Be an Effective Treatment Option for Acute Pyelonephritis When the Minimum Inhibitory Concentration of Levofloxacin for the Causative Escherichia coli Is ≤16 mg/L. Antibiotics, 10(1), 37. doi: 10.3390/antibiotics10010037
Type
Article
ISSN
2079-6382
Source
https://www.mdpi.com/2079-6382/10/1/37
DOI
10.3390/antibiotics10010037
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43570
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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