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Impact of statin pretreatment on the complications of carotid stenting in asymptomatic patients: observational study

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Author(s)
Seong Hwa JangDoo Hyuk KwonMoon-Ku HanHyungjong ParkSung-Il SohnHuimahn ChoiJeong-Ho Hong
Keimyung Author(s)
Park, Hyung JongSohn, Sung IlHong, Jeong Ho
Department
Dept. of Neurology (신경과학)
Journal Title
BMC Neurol
Issued Date
2021
Volume
21
Issue
1
Keyword
Carotid stenosisStentsComplicationsStatin
Abstract
Background:
Carotid stenosis is a known risk factor for ischemic stroke, and carotid artery stenting is an effective preventive procedure. However, the stroke risk reduction for asymptomatic patients is small. Therefore, it is important to reduce the risk of complications, particularly in asymptomatic carotid stenosis. Statins are known to reduce the overall risk of periprocedural complications, although there is a lack of data focusing on asymptomatic patients. We aimed to investigate whether different doses of statin pretreatment can reduce periprocedural complications of carotid artery stenting (CAS) in patients with asymptomatic carotid artery stenosis.

Methods:
Between July 2003 and June 2013, 276 consecutive patients received CAS for asymptomatic carotid stenosis. Periprocedural complications included the outcome of stroke, myocardial infarction, or death within 30 days of CAS. Statin pretreatment was categorized as no-statin (n = 87, 31.5%), standard-dose (< 40 mg, n = 139, 50.4%), and high-dose statin (≥40 mg, n = 50, 18.1%) according to the atorvastatin equivalent dose. The Cochran-Armitage (CA) trend test was performed to investigate the association of periprocedural complications with statin dose.

Results:
The overall periprocedural complication rate was 3.3%. There was no significant difference in the risk of periprocedural complications between the three groups (no statin: n = 3 [3.4%]; standard-dose: n = 4 [2.9%]; high-dose n = 2 [4.0%] p = 0.923). The CA trend test did not demonstrate a trend in the proportion of periprocedural complications across increasing statin equivalent doses (p = 0.919).

Conclusions:
Statin pretreatment before CAS showed neither absolute nor dose-dependent effects against periprocedural complications in asymptomatic patients undergoing CAS.
Keimyung Author(s)(Kor)
박형종
손성일
홍정호
Publisher
School of Medicine (의과대학)
Citation
Seong Hwa Jang et al. (2021). Impact of statin pretreatment on the complications of carotid stenting in asymptomatic patients: observational study. BMC Neurol, 21(1), 75. doi: 10.1186/s12883-021-02104-z
Type
Article
ISSN
1471-2377
Source
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02104-z
DOI
10.1186/s12883-021-02104-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43579
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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