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Prevalence and Predictive Factors for Upfront Dose Reduction of the First Cycle of First-Line Chemotherapy in Older Adults with Metastatic Solid Cancer: Korean Cancer Study Group (KCSG) Multicenter Study

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Author(s)
In Gyu HwangMinsuk KwonJin Won KimSe Hyun KimYun-Gyoo LeeJin Young KimSu-Jin KohYoon Ho KoSeong Hoon ShinSoojung HongTae-Yong KimSun Young KimHyun Jung KimHyo Jung KimMyung Ah LeeJung Hye KwonYong Sang HongKyung Hee LeeSung Hwa BaeDong-Hoe KooJee Hyun KimIn Sook Woo
Keimyung Author(s)
Kim, Jin Young
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancers (Basel)
Issued Date
2021
Volume
13
Issue
2
Keyword
predictivedosingchemotherapyolder adults
Abstract
Old age alone does not reflect an intolerability to chemotherapy. However, upfront dose reduction (UDR) of the first cycle of first-line palliative chemotherapy has sometimes been chosen by physicians for older adults with metastatic cancer due to concerns regarding adverse events. The development of predictive factors for UDR of palliative chemotherapy would be helpful for treatment planning among older adults. This was a secondary analysis of a study on predicting adverse events of first-line palliative chemotherapy in 296 patients (≥70 years) with solid cancer. We assessed the prevalence of UDR of the first cycle of first-line chemotherapy and the association of UDR with the variables of geriatric assessment (GA) and chemotherapy compliance. Among the 296 patients, 177 (59.8%) patients were treated with UDR. The mean percentage of UDR for the total patient group was 19.2% (range: 4–47%) of the standard dose. In a multivariate analysis, poor performance status (PS) and living without a spouse were independent predictive factors of UDR of first-line palliative chemotherapy in older adults. Patients with UDR showed fewer grade 3–5 adverse events versus the standard dose group. Study completion as planned was significantly higher in the UDR group versus the standard dose group. Older adults with UDR better tolerated chemotherapy than patients with a standard dose.
Keimyung Author(s)(Kor)
김진영
Publisher
School of Medicine (의과대학)
Citation
In Gyu Hwang et al. (2021). Prevalence and Predictive Factors for Upfront Dose Reduction of the First Cycle of First-Line Chemotherapy in Older Adults with Metastatic Solid Cancer: Korean Cancer Study Group (KCSG) Multicenter Study. Cancers (Basel), 13(2), 331. doi: 10.3390/cancers13020331
Type
Article
ISSN
2072-6694
Source
https://www.mdpi.com/2072-6694/13/2/331
DOI
10.3390/cancers13020331
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43586
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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