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Treatment Outcomes of Pediatric Acute Myeloid Leukemia in the Yeungnam Region: A Multicenter Retrospective Study of the Study Alliance of Yeungnam Pediatric Hematology-Oncology (SAYPH)

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Author(s)
Jae Min LeeEu Jeen YangKyung Mi ParkYoung-Ho LeeHeewon ChuehJeong Ok HahJi Kyoung ParkJae Young LimEun Sil ParkSang Kyu ParkHeung Sik KimYe Jee ShimJeong A. ParkEun Jin ChoiKun Soo LeeJi Yoon KimYoung Tak Lim
Keimyung Author(s)
Kim, Heung SikShim, Ye Jee
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Children (Basel)
Issued Date
2021
Volume
8
Issue
2
Keyword
acute myeloid leukemiahematopoietic stem cell transplantationprognosispediatricchildhoodKorea
Abstract
Acute myeloid leukemia (AML) is the second most common pediatric leukemia, with a survival rate of 70%. In this retrospective study, we evaluated the treatment outcomes of pediatric AML among 144 patients diagnosed between 2000 and 2013. After induction, 80.6% of patients achieved complete remission (CR). The 5-year overall survival (OS) and event-free survival (EFS) rates were 58.8 ± 4.2% and 49.8 ± 4.2%, respectively. Based on the response to induction therapy, the 5-year OS was 66.9 ± 5.7% in patients with CR (p < 0.001). Ninety-nine patients with CR after induction therapy were examined, and their 5-year OS and EFS were 66.4 ± 4.9% and 56.3 ± 5.1%, respectively. The 5-year OS rates according to treatment were 59.9 ± 7.4% in the chemotherapy group and 72.3 ± 6.3% in the hematopoietic stem cell transplantation (HSCT) group (p = 0.089). The EFS was 50.1 ± 7.4% in the chemotherapy group and 61.7 ± 6.9% in the HSCT group (p = 0.098). OS and EFS according to cytogenetics were insignificant. Our findings confirmed that the response to induction treatment was important for survival and HSCT had no significant survival benefits compared with those of chemotherapy. Moreover, many early induction deaths under the age of 2 years were observed.
Keimyung Author(s)(Kor)
김흥식
심예지
Publisher
School of Medicine (의과대학)
Citation
Jae Min Lee et al. (2021). Treatment Outcomes of Pediatric Acute Myeloid Leukemia in the Yeungnam Region: A Multicenter Retrospective Study of the Study Alliance of Yeungnam Pediatric Hematology-Oncology (SAYPH). Children (Basel), 8(2), 109. doi: 10.3390/children8020109
Type
Article
ISSN
2227-9067
Source
https://www.mdpi.com/2227-9067/8/2/109
DOI
10.3390/children8020109
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43588
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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