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Clinical features and prognostic factors of critically ill patients with COVID-19 in Daegu, South Korea: A multi-center retrospective study

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Author(s)
Kim, Eun JinLee, Yong HoonPark, Jae SeokLee, JaeheeLee, Shin YupKim, YeonjaeKwon, Yong ShikJang, Jong GeolShin, Kyeong-CheolKim, Kyung ChanChoi, Eun Young
Keimyung Author(s)
Park, Jae Seok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Medicine (Baltimore)
Issued Date
2021
Volume
100
Issue
7
Keyword
COVID-19critically ill
Abstract
To describe the clinical and demographic characteristics of critically ill patients with COVID-19 in Daegu, South Korea, and to explore the risk factors for in-hospital mortality in these patients.

Retrospective cohort study of 110 critically ill patients with COVID-19 admitted to the ICU in Daegu, South Korea, between February 18 and April 5, 2020. The final date of follow-up was April 20, 2020.

A total of 110 patient medical records were reviewed. The median age was 71 years (interquartile range [IQR] = 63–78 years). During the study period, 47 patients (42.7%) died in the hospital. The most common SARS-CoV-2 infection related complication was acute respiratory distress syndrome (ARDS) in 95 patients (86.4%). Of the 79 patients (71.8%) who received invasive mechanical ventilation, 46 (58.2%) received neuromuscular blockade injection, and 19 (24.1%) received ECMO treatment. All patients received antibiotic injection, 99 patients (90%) received hydroxychloroquine, 96 patients (87.3%) received lopinavir-ritonavir antiviral medication, and 14 patients (12.7%) received other antiviral agents, including darunavir-cobicistat and emtricitabine-tenofovir. In the multivariable logistic regression model, the odds ratio of in-hospital death was higher with APACHE II score (OR = 1.126; 95% CI = 1.014–1.252; P = .027).

The in-hospital mortality rate of critically ill patients with COVID-19 was approximately 40%. Higher APACHE II score at admission was an independent risk factor for death in these patients.
Keimyung Author(s)(Kor)
박재석
Publisher
School of Medicine (의과대학)
Citation
Kim, Eun Jin et al. (2021). Clinical features and prognostic factors of critically ill patients with COVID-19 in Daegu, South Korea: A multi-center retrospective study. Medicine (Baltimore), 100(7), e24437. doi: 10.1097/MD.0000000000024437
Type
Article
ISSN
1536-5964
Source
https://journals.lww.com/md-journal/Fulltext/2021/02190/Clinical_features_and_prognostic_factors_of.15.aspx
DOI
10.1097/MD.0000000000024437
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43639
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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