계명대학교 의학도서관 Repository

Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score

Metadata Downloads
Author(s)
Soonmyung PaikYoungmee KwonMoo Hyun LeeJi Ye KimDa Kyung LeeWon Jeong ChoEun Young LeeEun Sook Lee
Keimyung Author(s)
Lee, Mu Sook
Department
Dept. of Radiology (영상의학)
Journal Title
NPJ Breast Cancer
Issued Date
2021
Volume
7
Abstract
Although Ki67 labeling index is a potential predictive marker for chemotherapy benefit, its clinical utility has been limited by the lack of a standard scoring method resulting in poor interobserver reproducibility. Especially, there is no consensus on the use of average versus hotspot score for reporting. In order to determine the best method for Ki67 scoring and validate manual scoring method proposed by the International Ki67 Working Group (IKWG), we systematically compared average versus hotspot score in 240 cases with a public domain image analysis program QuPath. We used OncotypeDx Recurrence Score (RS) as a benchmark to compare the potential clinical utility of each scoring methods. Both average and hotspot scores showed statistically significant but only modest correlation with OncotypeDx RS. Only hotspot score could meaningfully distinguish RS low-risk versus high-risk patients. However, hotspot score was less reproducible limiting its clinical utility. In summary, our data demonstrate that utility of the Ki67 labeling index is influenced by the choice of scoring method.
Keimyung Author(s)(Kor)
이무숙
Publisher
School of Medicine (의과대학)
Citation
Soonmyung Paik et al. (2021). Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score. NPJ Breast Cancer, 7, 13. doi: 10.1038/s41523-021-00221-z
Type
Article
ISSN
2374-4677
Source
https://www.nature.com/articles/s41523-021-00221-z
DOI
10.1038/s41523-021-00221-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43642
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.