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Relationship between proteinuria and optical coherence tomographic features of the chorioretina in patients with pre-eclampsia

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Author(s)
Kyu Young ShimJin Gon BaeJae Kyoung LeeYu Cheol Kim
Keimyung Author(s)
Bae, Jin GonKim, Yu Cheol
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Ophthalmology (안과학)
Journal Title
PLoS One
Issued Date
2021
Volume
16
Issue
5
Abstract
This retrospective study aimed to evaluate the correlation between ophthalmologic factors and proteinuria in patients with pre-eclampsia using swept-source optical coherence tomography (OCT) and OCT angiography. In total, 61 pregnant patients diagnosed with pre-eclampsia were recruited during their hospital stay. The authors investigated the relationship between urine protein–creatinine ratio (PCR) and chorioretinal measurements including choroidal thickness (CT), choroidal vascularity index (CVI), foveal avascular zone (FAZ), vascular density (VD), ganglion cell layer+ (GCL+) and GCL++. The associations between mean arterial pressure (MAP) and ophthalmologic factors were also evaluated. Central subfield CT of the right eye (p = 0.031) and paracentral CT of both eyes were related to higher PCR (≥1.35 mg/mg). A significant association with PCR after logarithm transformation was noted (r = 0.284, p = 0.026). Retinal measurements (FAZ, VD, GCL+ and GCL++) and CVI were not related with PCR. There was a positive association between MAP and PCR after logarithm transformation (r = 0.296, p = 0.021); however, chorioretinal factors were not related with MAP. In pregnant women with pre-eclampsia, CT using OCT is a novel factor that is correlated with PCR. Ocular structural alteration in patients with pre-eclampsia may be one of systemic vascular changes caused by pre-eclampsia rather than hypertension.
Keimyung Author(s)(Kor)
배진곤
김유철
Publisher
School of Medicine (의과대학)
Citation
Kyu Young Shim et al. (2021). Relationship between proteinuria and optical coherence tomographic features of the chorioretina in patients with pre-eclampsia. PLoS One, 16(5), e0251933. doi: 10.1371/journal.pone.0251933
Type
Article
ISSN
1932-6203
Source
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0251933
DOI
10.1371/journal.pone.0251933
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43650
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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