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The clinical significance of preoperative C-reactive protein/albumin ratio in patients with resected extrahepatic bile duct cancer

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Author(s)
Du Hyun SongIn Kuk ChoDong Woo ShinJong-chan LeeJai Young ChoYoo-Seok YoonJin-Hyeok HwangHo-Seong HanJaihwan Kim
Keimyung Author(s)
Shin, Dong Woo
Department
Dept. of Internal Medicine (내과학)
Journal Title
Surg Today
Issued Date
2021
Volume
51
Keyword
C-reactive proteinAlbuminPerihilar bile duct cancerDistal bile duct cancerExtrahepatic cholangiocarcinoma
Abstract
Purpose:
The C-reactive protein (CRP)/albumin ratio has been identified as a potential prognostic factor for several malignancies. We, therefore, assessed the prognostic role of the CRP/albumin ratio in resected extrahepatic cholangiocarcinoma (EC).

Materials and methods:
A total of 235 patients were retrospectively analyzed between March 2005 and December 2017. The correlations among the preoperative CRP/albumin ratio, clinicopathological factors, and clinical outcomes were investigated.

Results:
There were 143 males (60.8%), and the median age at the diagnosis was 70.1 (range 41.0–85.5) years. Patients were diagnosed with perihilar bile duct cancer (n = 61) and distal bile duct cancer (n = 174). The median recurrence-free survival and overall survival were 32.7 and 38.7 months, respectively. The optimal prognostic cut-off point of the CRP/albumin ratio for the survival was 0.18 (× 103). According to the Kaplan–Meier analysis with a log-rank test, the high CRP/albumin ratio group (≥ 0.18) had a significantly shorter overall survival than the low CRP/albumin ratio group (< 0.18) (29.8 vs. 54.6 months, p = 0.002). A multivariate logistic regression analysis for the overall survival showed that CA19-9 ≥ 37 and a high CRP/albumin ratio were associated with a shorter overall survival.

Conclusion:
A high CRP/albumin ratio appears to be significantly associated with clinically worse outcomes in patients with resected EC.
Keimyung Author(s)(Kor)
신동우
Publisher
School of Medicine (의과대학)
Citation
Du Hyun Song et al. (2021). The clinical significance of preoperative C-reactive protein/albumin ratio in patients with resected extrahepatic bile duct cancer. Surg Today, 51, 978–985. doi: 10.1007/s00595-020-02188-z
Type
Article
ISSN
1436-2813
Source
https://link.springer.com/article/10.1007%2Fs00595-020-02188-z
DOI
10.1007/s00595-020-02188-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43662
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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