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Epidemiology of Venous Thromboembolism and Treatment Pattern of Oral Anticoagulation in Korea, 2009–2016: a Nationwide Study Based on the National Health Insurance Service Database

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Author(s)
Hyung Yoon KimSung-A ChangKye Hun KimJae-Young KimWoo-Keun SeoHyungseop KimJeong-Sook SeoSung-Hee ShinSang Jae RheeSun Hwa LeeJung Sun Cho
Keimyung Author(s)
Kim, Hyung Seop
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Cardiovasc Imaging
Issued Date
2021
Volume
29
Issue
3
Keyword
Annual incidenceOral anticoagulantsNOACsTemporal trendVenous thromboembolism
Abstract
BACKGROUND:
The annual incidence of venous thromboembolism (VTE) is increasing, and the treatment pattern of oral anticoagulants (OACs) has changed with introduction of new oral anticoagulants (NOACs). The aims of this study were to assess the annual incidence of VTE in a Korean population and the change of treatment pattern with availability of NOACs using a population-based database.

METHODS:
Using the Korean National Health Insurance Services database, we identified patients diagnosed with VTE between 2009 and 2016. The annual prevalence of VTE and clinical characteristics and treatment pattern were investigated. The annual incidence of VTE was calculated using direct and indirect methods using the estimated Korean population in 2009 as the reference.

RESULTS:
The annual incidence of VTE in Korean has increased yearly from 23.9 per 100,000 in 2009 to 42.2 in 2016. The overall rate of OAC prescription for VTE treatment increased from 55.9% to 68% in the same time period. The rate of initiation of NOAC treatment greatly increased, particularly from 2013 onwards, with a 20-fold increase from 2009 to 2016 (2.1% vs. 54.3%).

CONCLUSIONS:
The annual incidence of VTE in Korea increased by almost two-fold from 2009 to 2016. The rate of initiation of NOAC treatment has increased substantially since 2013, and these agents have surpassed VKAs as the anticoagulant of choice for VTE. This temporal pattern of OAC prescription is consistent with the current clinical guidelines, which indicate NOACs over the warfarin in patients with VTE.
Keimyung Author(s)(Kor)
김형섭
Publisher
School of Medicine (의과대학)
Citation
Hyung Yoon Kim et al. (2021). Epidemiology of Venous Thromboembolism and Treatment Pattern of Oral Anticoagulation in Korea, 2009–2016: a Nationwide Study Based on the National Health Insurance Service Database. J Cardiovasc Imaging, 29(3), 265–278. doi: 10.4250/jcvi.2021.0014
Type
Article
ISSN
2586-7296
Source
https://e-jcvi.org/search.php?where=aview&id=10.4250/jcvi.2021.0014&code=3059JCVI&vmode=FULL
DOI
10.4250/jcvi.2021.0014
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43677
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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