계명대학교 의학도서관 Repository

Discrepancy between Cytology and Histology in Cervical Cancer Screening: a Multicenter Retrospective Study (KGOG 1040)

Metadata Downloads
Author(s)
Yung-Taek OuhJi Jeong ParkMinjoo KangMiseon KimJae Yun SongSo Jin ShinSeung-Hyuk ShimHeon Jong YooMaria LeeSung-Jong LeeWhan ShinGun Oh ChongMin Chul ChoiChel Hun Choiand Kyung-Jin Min
Keimyung Author(s)
Shin, So Jin
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
J Korean Med Sci
Issued Date
2021
Volume
36
Issue
24
Keyword
HPVCervical CytologyColposcopyDiscrepancyHistology
Abstract
Background:
Cervical cancer is the fourth common cancer in women worldwide. The Papanicolau test is the primary screening procedure to detect abnormal cervical cells. Colposcopy is the main procedure for discriminating high-grade cervical lesions. The study aimed at clarifying the discrepancy between cervical cytology and colposcopic biopsy histology as well as confounding factors.

Methods:
Eligible patients visited thirteen tertiary hospitals for colposcopic biopsy following cervical cytology and human papillomavirus (HPV) genotypes between January and December 2018. Baseline characteristics including age, body mass index (BMI), and parity were collected.

Results:
In our study, 3,798 eligible patients were included. Mean age of patients was 42.7 (19–88) years and mean BMI was 22.5 (16.9–34.1) kg/m2. The referred cervical cytologic findings consisted of 495 normal, 1,390 atypical squamous cells of undetermined significance, 380 atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion, 792 low-grade squamous intraepithelial lesion, 593 high-grade squamous intraepithelial lesion, 79 atypical glandular cells, 46 squamous cell carcinoma, and 23 adenocarcinoma. HPV-positive findings were found in 3,008 (79.2%) patients and were not detected in 914 (24.1%) cases. The risk of unexpected low-grade lesions from histology was higher in patients > 45 years (odds ratio [OR], 2.137; 95% confidence intervals [CIs], 1.475–3.096). In contrast, the risk of unexpected high-grade lesions from colposcopic biopsy was lower in patients ≥ 45 years (OR, 0.530; 95% CI, 0.367–0.747) and HPV 16/18 infection was higher than other HPV (OR, 1.848; 95% CI, 1.385–2.469).

Conclusion:
Age and HPV genotypes were responsible for the discrepancies between cytology and histology. Precautions should be taken for women over the age of 45 in triage for colposcopy in order to avoid unnecessary testing.
Keimyung Author(s)(Kor)
신소진
Publisher
School of Medicine (의과대학)
Citation
Yung-Taek Ouh et al. (2021). Discrepancy between Cytology and Histology in Cervical Cancer Screening: a Multicenter Retrospective Study (KGOG 1040). J Korean Med Sci, 36(24), 1–9. doi: 10.3346/jkms.2021.36.e164
Type
Article
ISSN
1598-6357
Source
https://jkms.org/search.php?where=aview&id=10.3346/jkms.2021.36.e164&code=0063JKMS&vmode=FULL
DOI
10.3346/jkms.2021.36.e164
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43681
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.