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Prognosis of patients with axillary lymph node metastases from occult breast cancer: analysis of multicenter data

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Author(s)
Haeyoung KimWon ParkSu Ssan KimSung Ja AhnYong Bae KimTae Hyun KimJin Hee KimJin-Hwa ChoiHae Jin ParkJee Suk ChangDoo Ho Choi
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Radiat Oncol J
Issued Date
2021
Volume
39
Issue
2
Keyword
Unknown primary neoplasmsBreast neoplasmLymph nodesRadiotherapy
Abstract
Purpose:
This study was conducted to evaluate prognosis of patients with level I/II axillary lymph node metastases from occult breast cancer (OBC).

Materials and Methods:
Data of 53 patients with OBC who received axillary lymph node dissection (ALND) positive/negative (+/–) breast-conserving surgery between 2001 and 2013 were retrospectively collected at seven hospitals in Korea. The median number of positive lymph nodes (+LNs) was 2. Seventeen patients (32.1%) had >3 +LNs. A total of 48 patients (90.6%) received radiotherapy. Extents of radiotherapy were as follows: whole-breast (WB; n = 11), regional lymph node (RLN; n = 2), and WB plus RLN (n = 35).

Results:
The median follow-up time was 85 months. Recurrence was found in four patients: two in the breast, one in RLN, and one in the breast and RLN. The 5-year and 7-year disease-free survival (DFS) rates were 96.1% and 93.5%, respectively. Molecular subtype and receipt of breast radiotherapy were significantly associated with DFS. Patients with estrogen receptor negative, progesterone receptor negative, and human epidermal growth factor receptor 2 negative (ER-/PR-/HER2-) subtype had significantly lower 7-year DFS than those with non-ER-/PR-/HER2- tumor (76.9% vs. 100.0%; p = 0.03). Whole breast irradiation (WBI) was significantly associated with a higher 7-year DFS rate (94.7% for WBI group vs. 83.3% for non-WBI group; p = 0.01). Other factors including patient's age, number of +LNs, taxane chemotherapy, and RLN irradiation were not associated with DFS.

Conclusion:
Patients with OBC achieved favorable outcome after ALND and breast-targeting treatment. Molecular subtype and receipt of WBI was significant factors for DFS.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Citation
Haeyoung Kim et al. (2021). Prognosis of patients with axillary lymph node metastases from occult breast cancer: analysis of multicenter data. Radiat Oncol J, 39(2), 107–112. doi: 10.3857/roj.2021.00241
Type
Article
ISSN
2234-3156
Source
https://www.e-roj.org/journal/view.php?number=1490
DOI
10.3857/roj.2021.00241
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43689
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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