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Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness

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Author(s)
Kyoung Tae KimSe Il KimYoung Rok DoHye Ra JungJang Hyuk Cho
Keimyung Author(s)
Do, Young RokJung, Hye RaCho, Jang Hyuk
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Journal Title
Yeungnam Univ J Med
Issued Date
2021
Volume
38
Issue
3
Keyword
Diffuse large B-cell lymphomaNeurolymphomatosisNeuropathySciatic nerve
Abstract
Neurolymphomatosis (NL) is defined as the involvement of the peripheral nervous system in lymphocytic invasion. It is a very rare form of lymphoma that may occur as an initial presentation or recurrence. It affects various peripheral nervous structures and can therefore mimic disc-related nerve root pathology or compressive mononeuropathy. NL often occurs in malignant B-cell non-Hodgkin lymphomas. Notwithstanding its aggressiveness or intractability, NL should be discriminated from other neurologic complications of lymphoma. Herein, we present a case of primary NL as the initial presentation of diffuse large B-cell lymphoma (DLBCL) of the sciatic nerve. The patient presented with weakness and pain in his left leg but had no obvious lesion explaining the neurologic deficit on initial lumbosacral and knee magnetic resonance imaging (MRI). NL of the left sciatic nerve at the greater sciatic foramen was diagnosed based on subsequent hip MRI, electrodiagnostic test, positron emission tomography/computed tomography, and nerve biopsy findings. Leg weakness slightly improved after chemotherapy and radiotherapy. We report a case wherein NL, a rare cause of leg weakness, manifested as the initial presentation of primary DLBCL involving the sciatic nerve at the greater sciatic foramen.
Keimyung Author(s)(Kor)
도영록
정혜라
조장혁
Publisher
School of Medicine (의과대학)
Citation
Kyoung Tae Kim et al. (2021). Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness. Yeungnam Univ J Med, 38(3), 258–263. doi: 10.12701/yujm.2021.00983
Type
Article
ISSN
2384-0293
Source
https://www.e-yujm.org/journal/view.php?number=2639
DOI
10.12701/yujm.2021.00983
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43690
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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