계명대학교 의학도서관 Repository

Nocturnal stridor in multiple system atrophy: Video-polysomnography and clinical features

Metadata Downloads
Author(s)
Ho-Sung RyuHyo Jae KimSooyeoun YouMi-Jung KimYoung Jin KimJuyeon KimKiju KimSang-Ahm Lee and Sun Ju Chung
Keimyung Author(s)
You, Soo Yeoun
Department
Dept. of Neurology (신경과학)
Journal Title
Parkinsonism Relat Disord
Issued Date
2021
Volume
89
Keyword
Multiple system atrophyVideo-polysomnographyNocturnal stridorAxial motor features
Abstract
Introduction:
Nocturnal stridor, a life-threatening condition linked to respiratory failure and sudden death during sleep, is a serious issue in patients with multiple system atrophy (MSA). However, little is known about polysomnographic findings and clinical features of MSA patients with nocturnal stridor. Hence, we investigated video-polysomnography (VPSG) findings and clinical features associated with nocturnal stridor in patients with MSA.

Methods:
We retrospectively analyzed the clinical data of patients with MSA (n = 49) who underwent overnight VPSG for the evaluation of sleep-disordered breathing. The presence of nocturnal stridor was confirmed based on overnight VPSG findings. Clinical data, including VPSG findings and clinical features, were compared between MSA patients with and without nocturnal stridor.

Results:
Nocturnal stridor was present in 31 (63.3%) patients with MSA. Patients with stridor showed significantly higher apnea-hypopnea, respiratory disturbance, and oxygen desaturation indices than those without stridor ( P = 0.024, P = 0.049, and P = 0.006, respectively). Patients with stridor had more severe axial motor features, more impaired activities of daily living, and longer disease duration than those without stridor ( P = 0.012, P = 0.036, and P = 0.003, respectively). However, there were no significant between-group differences in sex, age at disease onset, MSA subtype, parkinsonian features, cerebellar ataxia, residual urine volume, or systolic and diastolic blood pressure change.

Conclusions:
MSA with nocturnal stridor is related to higher apnea indices in conjunction with higher O 2 desaturation index, more severe axial motor features, more impaired activities of daily living, and longer disease duration.
Keimyung Author(s)(Kor)
유수연
Publisher
School of Medicine (의과대학)
Citation
Ho-Sung Ryu et al. (2021). Nocturnal stridor in multiple system atrophy: Video-polysomnography and clinical features. Parkinsonism Relat Disord, 89, 48–53. doi: 10.1016/j.parkreldis.2021.03.015
Type
Article
ISSN
1873-5126
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1353802021001085
DOI
10.1016/j.parkreldis.2021.03.015
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43713
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록
  • 관련 파일이 존재하지 않습니다.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.