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Causal Effects of Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism on Kidney Function: A Mendelian Randomization Study

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Author(s)
Sehoon ParkSoojin LeeYaerim KimYeonhee LeeMin Woo KangKwangsoo KimYong Chul KimSeung Seok HanHajeong LeeJung Pyo LeeKwon Wook JooChun Soo LimYon Su KimDong Ki Kim
Keimyung Author(s)
Kim, Yae Rim
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Am Soc Nephrol
Issued Date
2021
Volume
32
Issue
6
Keyword
wellbeingpsychologicaldepressionchronic kidney diseaseMendelian randomization
Abstract
Background:
Further investigation of the causal effects of psychologic wellbeing on kidney function is warranted.

Methods:
In this Mendelian randomization (MR) study, genetic instruments for positive affect, life satisfaction, depressive symptoms, and neuroticism were introduced from a previous genome-wide association study meta-analysis of European individuals. Summary-level MR was performed using the CKDGen data of European ancestry (n=567,460), and additional allele score–based MR was performed in the individual-level data of White British UK Biobank participants (n=321,024).

Results:
In summary-level MR with the CKDGen data, depressive symptoms were a significant causative factor for kidney function impairment (CKD OR, 1.45; 95% confidence interval, 1.07 to 1.96; eGFR change [%] beta −2.18; 95% confidence interval, −3.61 to −0.72) and pleiotropy-robust sensitivity analysis results supported the causal estimates. A genetic predisposition for positive affect was significantly associated with better kidney function (CKD OR, 0.69; 95% confidence interval, 0.52 to 0.91), eGFR change [%] beta 1.50; 95% confidence interval, 0.09 to 2.93) and sensitivity MR analysis results supported the finding for CKD outcome, but was nonsignificant for eGFR. Life satisfaction and neuroticism exposures showed nonsignificant causal estimates. In the UK Biobank with covariate-adjusted allele score MR analysis, allele scores for positive affect and life satisfaction were causally associated with reduced risk of CKD and higher eGFR. In contrast, neuroticism allele score was associated with increased risk of CKD and lower eGFR, and depressive symptoms allele score was associated with lower eGFR, but showed nonsignificant association with CKD.

Conclusions:
Health care providers in the nephrology field should be aware of the causal linkage between psychologic wellbeing and kidney function.
Keimyung Author(s)(Kor)
김예림
Publisher
School of Medicine (의과대학)
Citation
Sehoon Park et al. (2021). Causal Effects of Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism on Kidney Function: A Mendelian Randomization Study. J Am Soc Nephrol, 32(6), 1484–1496. doi: 10.1681/ASN.2020071086
Type
Article
ISSN
1533-3450
Source
https://jasn.asnjournals.org/content/32/6/1484.long
DOI
10.1681/ASN.2020071086
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43733
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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