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Gender difference in the overlap of irritable bowel syndrome and functional dyspepsia: a prospective nationwide multicenter study in Korea

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Author(s)
Kwangwoo NamNayoung KimHyun Joo SongGwang Ho BaikSuck Chei ChoiHyun Jin KimJu Yup LeeKyung Sik ParkSun-Young ParkSeun Ja Park
Keimyung Author(s)
Lee, Ju YupPark, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Gastroenterol
Issued Date
2021
Volume
56
Issue
6
Keyword
GenderDyspepsiaIrritable bowel syndromeOverlapFunctional gastrointestinal disorders
Abstract
Background:
The overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS) is associated with more severe gastrointestinal (GI) symptoms and lower quality of life. However, the gender differences in FD-IBS overlap remain unclear. This study aimed to investigate the gender differences in patients with FD-IBS overlap.

Methods:
Controls and cases were prospectively enrolled from July 2019 to June 2020 at nine tertiary referral centers. The patients underwent esophagogastroduodenoscopy, and their symptoms were evaluated using a questionnaire including GI symptom-related items and the Hospital Anxiety Depression Scale (HADS). FD and IBS were diagnosed according to the Rome IV criteria, and the clinical characteristics of the FD-IBS overlap group were compared with those of the FD-only or IBS-only group.

Results:
Among 667 subjects (334 healthy controls, 168 with FD-only, 37 with IBS-only, 128 with FD-IBS overlap), the FD-IBS overlap group (19.2%) showed a higher rate of preference for dairy products, a higher rate of history of Helicobacter pylori eradication, and higher HADS scores than the non-overlap group (P < 0.05). In the FD-IBS overlap group, men complained of reflux symptom and loose/watery stools more than women (P < 0.05), whereas women showed more severe GI symptoms, especially epigastric pain/burning symptoms, and higher depression scores than men (all P < 0.05).

Conclusions:
FD-IBS overlap patients are associated with severe upper GI symptoms and depression compared to non-overlap patients. Moreover, women with FD-IBS overlap experience more severe GI and depression symptoms than men.
Keimyung Author(s)(Kor)
이주엽
박경식
Publisher
School of Medicine (의과대학)
Citation
Kwangwoo Nam et al. (2021). Gender difference in the overlap of irritable bowel syndrome and functional dyspepsia: a prospective nationwide multicenter study in Korea. J Gastroenterol, 56(6), 537–546. doi: 10.1007/s00535-021-01775-2
Type
Article
ISSN
1435-5922
Source
https://link.springer.com/article/10.1007%2Fs00535-021-01775-2
DOI
10.1007/s00535-021-01775-2
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43735
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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