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Comparison of Oncologic Outcomes between Transduodenal Ampullectomy and Pancreatoduodenectomy in Ampulla of Vater Cancer: Korean Multicenter Study

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Author(s)
Seung-Soo HongSung-Sik HanWooil KwonJin-Young JangHee-Joon KimChol-Kyoon ChoKeun-Soo AhnJae-Do YangYoungmok ParkSeog-Ki MinJu-Ik MoonYoung-Hoon RohSeung-Eun LeeJoon-Seong ParkSang-Geol KimChi-Young JeongJin-Seok HeoHo-Kyoung Hwang
Keimyung Author(s)
Ahn, Keun Soo
Department
Dept. of Surgery (외과학)
Journal Title
Cancers (Basel)
Issued Date
2021
Volume
13
Issue
9
Keyword
ampulla of Vater cancertransduodenal ampullectomypancreaticoduodenectomy
Abstract
This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis–T2 stage) from January 2000 to September 2019 were collected from 15 institutions. The clinicopathologic characteristics and survival outcomes were compared between the PPPD and TDA groups. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior in the PPPD group was more aggressive than that in the TDA group at all T stages: larger tumor size (p = 0.034), advanced T stage (p < 0.001), aggressive cell differentiation (p < 0.001), and more lymphovascular invasion (p = 0.002). Five-year disease-free survival (DFS) and overall survival (OS) did not differ between the two groups when considering all T stages or only the Tis+T1 group. Among T1 patients, PPPD produced significantly better DFS (PPPD vs. TDA, 84.8% vs. 66.6%, p = 0.040) and superior OS (PPPD vs. TDA, 89.1% vs. 68.0%, p = 0.056) than TDA. Lymph node dissection (LND) in the TDA group did not affect DFS or OS (TDA + LND vs. TDA-only, DFS, p = 0.784; OS, p = 0.870). In conclusion, PPPD should be the standard procedure for early AoV cancer.
Keimyung Author(s)(Kor)
안근수
Publisher
School of Medicine (의과대학)
Citation
Seung-Soo Hong et al. (2021). Comparison of Oncologic Outcomes between Transduodenal Ampullectomy and Pancreatoduodenectomy in Ampulla of Vater Cancer: Korean Multicenter Study. Cancers (Basel), 13(9), 2038. doi: 10.3390/cancers13092038
Type
Article
ISSN
2072-6694
Source
https://www.mdpi.com/2072-6694/13/9/2038
DOI
10.3390/cancers13092038
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43751
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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