계명대학교 의학도서관 Repository

Immediate and Long-Term Outcomes of Reperfusion Therapy in Patients With Cancer

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Author(s)
Joonsang YooYoung Dae KimHyungjong ParkByung Moon KimOh Young BangHyeon Chang KimEuna HanDong Joon KimJoonnyung HeoMinyoung KimJin Kyo ChoiKyung-Yul LeeHye Sun LeeDong Hoon ShinHye-Yeon ChoiSung-Il SohnJeong-Ho HongJong Yun LeeJang-Hyun BaekGyu Sik KimWoo-Keun SeoJong-Won ChungSeo Hyun KimTae-Jin SongSang Won HanJoong Hyun ParkJinkwon KimYo Han JungHan-Jin ChoSeong Hwan AhnSung Ik LeeKwon-Duk SeoJi Hoe HeoHyo Suk Nam
Keimyung Author(s)
Park, Hyung JongSohn, Sung IlHong, Jeong Ho
Department
Dept. of Neurology (신경과학)
Journal Title
Stroke
Issued Date
2021
Volume
52
Issue
6
Keyword
ischemic strokeneoplasmsregistriesreperfusionthrombectomy
Abstract
Background and Purpose:
Patients with acute stroke are often accompanied by comorbidities, such as active cancer. However, adequate treatment guidelines are not available for these patients. The purpose of this study was to evaluate the association between cancer and the outcomes of reperfusion therapy in patients with stroke.

Methods:
We compared treatment outcomes in patients who underwent reperfusion therapy, using a nationwide reperfusion therapy registry. We divided the patients into 3 groups according to cancer activity: active cancer, nonactive cancer, and without a history of cancer. We investigated reperfusion processes, 24-hour neurological improvement, adverse events, 3-month functional outcome, and 6-month survival and related factors after reperfusion therapy.

Results:
Among 1338 patients who underwent reperfusion therapy, 62 patients (4.6%) had active cancer, 78 patients (5.8%) had nonactive cancer, and 1198 patients (89.5%) had no history of cancer. Of the enrolled patients, 969 patients received intravenous thrombolysis and 685 patients underwent endovascular treatment (316 patients received combined therapy). Patients with active cancer had more comorbidities and experienced more severe strokes; however, they showed similar 24-hour neurological improvement and adverse events, including cerebral hemorrhage, compared with the other groups. Although the functional outcome at 3 months was poorer than the other groups, 36.4% of patients with active cancer showed functional independence. Additionally, 52.9% of the patients with determined stroke etiology showed functional independence despite active cancer. During the 6-month follow-up, 46.6% of patients with active cancer died, and active cancer was independently associated with poor survival (hazard ratio, 3.973 [95% CI, 2.528–6.245]).

Conclusions:
In patients with active cancer, reperfusion therapy showed similar adverse events and short-term outcomes to that of other groups. While long-term prognosis was worse in the active cancer group than the nonactive cancer groups, not negligible number of patients had good functional outcomes, especially those with determined stroke mechanisms.
Keimyung Author(s)(Kor)
박형종
손성일
홍정호
Publisher
School of Medicine (의과대학)
Citation
Joonsang Yoo et al. (2021). Immediate and Long-Term Outcomes of Reperfusion Therapy in Patients With Cancer. Stroke, 52(6), 2026–2034. doi: 10.1161/STROKEAHA.120.032380
Type
Article
ISSN
1524-4628
Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.032380
DOI
10.1161/STROKEAHA.120.032380
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43757
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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