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Long interspersed nuclear element-1 hypomethylation is associated with poor outcomes via the activation of ST18 in human hepatocellular carcinoma

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Author(s)
Lee, Yu RimKim, GyeonghwaLee, Hye WonTak, Won YoungPark, Soo YoungJang, Se YoungKweon, Young OhPark, Jung GilHan, Young SeokChun, Jae MinHan, Ja RyungHur, Keun
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
Medicine (Baltimore)
Issued Date
2021
Volume
100
Issue
16
Keyword
hepatocellular carcinomalong interspersed nuclear element-1methylationprognosissuppression of tumorigenicity 18
Abstract
The level of long interspersed nuclear element-1 (LINE-1) methylation, representing the global deoxyribonucleic acid methylation level, could contribute to the prognosis of cancer via the activation of oncogenes. This study was performed to evaluate the prognostic implications of LINE-1 hypomethylation in patients with hepatocellular carcinoma (HCC) and the possible mechanisms related to oncogene activation.

Seventy-seven HCC patients between October 2014 and September 2015 were enrolled in this prospective study. Quantitative pyrosequencing was performed to assess the LINE-1 methylation level of HCC and matched non-HCC tissue samples. The expression of suppression of tumorigenicity 18 was measured by immunohistochemistry and its correlation with LINE-1 methylation levels was examined.

LINE-1 was significantly hypomethylated in the HCC tissue compared with the matched nontumor tissue (64.0 ± 11.6% vs 75.6 ± 4.0%, P < .001). LINE-1 hypomethylation was an independent risk factor for overall survival (hazard ratio = 27.291, P = .032) and disease progression (hazard ratio = 5.298, P = .005). The expression of suppression of tumorigenicity 18 was higher in the hypomethylated LINE-1 HCC tissue than the hypermethylated LINE-1 tumor tissue (P = .030).

LINE-1 hypomethylation may serve as a potential prognostic marker for patients with HCC.
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine (의과대학)
Citation
Lee, Yu Rim et al. (2021). Long interspersed nuclear element-1 hypomethylation is associated with poor outcomes via the activation of ST18 in human hepatocellular carcinoma. Medicine (Baltimore), 100(16), e25552. doi: 10.1097/MD.0000000000025552
Type
Article
ISSN
1536-5964
Source
https://journals.lww.com/md-journal/Fulltext/2021/04230/Long_interspersed_nuclear_element_1.53.aspx
DOI
10.1097/MD.0000000000025552
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43758
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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