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Comorbidity index for predicting mortality at 6 months after reperfusion therapy

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Author(s)
Hyo Suk NamYoung Dae KimJoonsang YooHyungjong ParkByung Moon KimOh Young BangHyeon Chang KimEuna HanDong Joon KimJoonyung HeoMinyoung KimJin Kyo ChoiKyung-Yul LeeHye Sun LeeDong Hoon ShinHye-Yeon ChoiSung-Il SohnJeong-Ho HongJong Yun LeeJang-Hyun BaekGyu Sik KimWoo-Keun SeoJong-Won ChungSeo Hyun KimTae-Jin SongSang Won HanJoong Hyun ParkJinkwon KimYo Han JungHan-Jin ChoSeong Hwan AhnSung Ik LeeKwon-Duk SeoJi Hoe Heo
Keimyung Author(s)
Park, Hyung JongSohn, Sung IlHong, Jeong Ho
Department
Dept. of Neurology (신경과학)
Journal Title
Sci Rep
Issued Date
2021
Volume
11
Abstract
The eligibility of reperfusion therapy has been expanded to increase the number of patients. However, it remains unclear the reperfusion therapy will be beneficial in stroke patients with various comorbidities. We developed a reperfusion comorbidity index for predicting 6-month mortality in patients with acute stroke receiving reperfusion therapy. The 19 comorbidities included in the Charlson comorbidity index were adopted and modified. We developed a statistical model and it was validated using data from a prospective cohort. Among 1026 patients in the retrospective nationwide reperfusion therapy registry, 845 (82.3%) had at least one comorbidity. As the number of comorbidities increased, the likelihood of mortality within 6 months also increased (p < 0.001). Six out of the 19 comorbidities were included for developing the reperfusion comorbidity index on the basis of the odds ratios in the multivariate logistic regression analysis. This index showed good prediction of 6-month mortality in the retrospective cohort (area under the curve [AUC], 0.747; 95% CI, 0.704–0.790) and in 333 patients in the prospective cohort (AUC, 0.784; 95% CI, 0.709–0.859). Consideration of comorbidities might be helpful for the prediction of the 6-month mortality in patients with acute ischemic stroke who receive reperfusion therapy.
Keimyung Author(s)(Kor)
박형종
손성일
홍정호
Publisher
School of Medicine (의과대학)
Citation
Hyo Suk Nam et al. (2021). Comorbidity index for predicting mortality at 6 months after reperfusion therapy. Sci Rep, 11, 5963. doi: 10.1038/s41598-021-85390-4
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-021-85390-4
DOI
10.1038/s41598-021-85390-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43759
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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