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Albuminuria Is Associated with Steatosis Burden in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease

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Author(s)
Eugene HanMi Kyung KimByoung Kuk JangHye Soon Kim
Keimyung Author(s)
Han, Eu GeneKim, Mi KyungJang, Byoung KukKim, Hye Soon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes Metab J
Issued Date
2021
Volume
45
Issue
5
Keyword
AlbuminuriaDiabetes mellitus, type 2Non-alcoholic fatty liver disease
Abstract
Background:
This study aimed to investigate the association between hepatic steatosis burden and albuminuria in Korean patients with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD).

Methods:
We recruited 100 patients with both T2DM and NAFLD, but without chronic kidney disease. Albuminuria was defined as a spot urinary albumin-to-creatinine ratio (ACR) ≥30 mg/g. Transient elastography was performed, and the steatosis burden was quantified by controlled attenuation parameter (CAP) with significant steatosis defined as CAP >302 dB/m.

Results:
The prevalence of significant steatosis and albuminuria was 56.0% and 21.0%, respectively. Subjects with significant steatosis were significantly younger and had a significantly shorter duration of T2DM, greater waist circumference, and higher body mass index, total cholesterol, triglyceride, and low density lipoprotein cholesterol levels, than subjects without severe NAFLD (all P<0.05). Albuminuria was higher in patients with significant steatosis than in patients without significant steatosis (32.1% vs. 6.8%, P=0.002). Urinary ACR showed a correlation with CAP (r=0.331, P=0.001), and multiple linear regression analysis revealed a significant association between a high degree of albuminuria and high CAP value (r=0.321, P=0.001). Additionally, multivariate logistic regression analysis demonstrated the independent association between urinary ACR and significant steatosis after adjustment for confounding factors including age, body mass index, duration of T2DM, low density lipoprotein level, and renin-angiotensin system blocker use (odds ratio, 1.88; 95% confidence interval, 1.31 to 2.71; P=0.001).

Conclusion:
T2DM patients with NAFLD had a higher prevalence of albuminuria, which correlated with their steatosis burden.
Keimyung Author(s)(Kor)
한유진
김미경
장병국
김혜순
Publisher
School of Medicine (의과대학)
Citation
Eugene Han et al. (2021). Albuminuria Is Associated with Steatosis Burden in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease. Diabetes Metab J, 45(5), 698–707. doi: 10.4093/dmj.2020.0118
Type
Article
ISSN
2233-6087
Source
https://www.e-dmj.org/journal/view.php?doi=10.4093/dmj.2020.0118
DOI
10.4093/dmj.2020.0118
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43764
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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