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Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy

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Author(s)
Won Kyung ChoJee Suk ChangSeung Gyu ParkNalee KimDoo Ho ChoiHaeyoung KimYong Bae KimWon ParkChang Ok Suh
Keimyung Author(s)
Park, Seung Gyu
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Breast
Issued Date
2021
Volume
59
Keyword
Regional lymph node irradiationInternal mammary nodeRadiation
Abstract
Background:
It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy.

Methods:
We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI ( n = 105, 30.2%) or without IMNI ( n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups.

Results:
After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045–0.966) and 0.460 (95% CI, 0.220–0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018).

Conclusions:
IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low.
Keimyung Author(s)(Kor)
박승규
Publisher
School of Medicine (의과대학)
Citation
Won Kyung Cho et al. (2021). Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy. Breast, 59, 37–43. doi: 10.1016/j.breast.2021.05.012
Type
Article
ISSN
0960-9776
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0960977621003842
DOI
10.1016/j.breast.2021.05.012
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43781
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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