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Association of Skeletal Muscle and Adipose Tissue Distribution with Histologic Severity of Non-Alcoholic Fatty Liver

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Author(s)
Min-Kyu KangJung-Hun BaekYoung-Oh KweonWon-Young TakSe-Young JangYu-Rim LeeKeun HurGyeonghwa KimHye-Won LeeMan-Hoon HanJoon-Hyuk ChoiSoo-Young ParkJung-Gil Park
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
Diagnostics (Basel)
Issued Date
2021
Volume
11
Issue
6
Keyword
non-alcoholic fatty liver diseasenon-alcoholic steatohepatitissarcopeniaadipose tissueskeletal musclebody composition
Abstract
Adipose tissue and skeletal muscle is associated with non-alcoholic fatty liver disease (NAFLD). This study evaluates the association between body composition and histologic severity in patients with NAFLD. Using the cross-sectional CT images at the level of L3 vertebra and the histologic findings of 178 patients with biopsy-proven NAFLD, we analyzed the correlation of the histologic findings to the skeletal muscle index (SMI), subcutaneous adipose tissue index (SATI), and visceral adipose tissue index (VATI), which is defined as the body composition area (cm2) by height squared (m2). The clinical and laboratory features with body composition were analyzed to determine the risk factors for advanced fibrosis. The VATI significantly increased in severe non-alcoholic steatohepatitis (NASH) or advanced fibrosis. In addition, the VATI was correlated with the NAFLD activity score (NAS) and the fibrosis stage. In multivariate analyses, age (odds ratio (OR), 1.09; 95% confidence interval (CI), 1.02–1.19; p = 0.025), severe NASH (OR, 8.66; 95% CI, 2.13–46.40; p = 0.005), and visceral adiposity (OR, 6.77; 95% CI, 1.81–29.90; p = 0.007) were independently associated with advanced fibrosis in patients with NAFLD. Visceral adiposity is correlated with the histologic severity of NAFLD, which is independently associated with advanced fibrosis.
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine (의과대학)
Citation
Min-Kyu Kang et al. (2021). Association of Skeletal Muscle and Adipose Tissue Distribution with Histologic Severity of Non-Alcoholic Fatty Liver. Diagnostics (Basel), 11(6), 1061. doi: 10.3390/diagnostics11061061
Type
Article
ISSN
2075-4418
Source
https://www.mdpi.com/2075-4418/11/6/1061
DOI
10.3390/diagnostics11061061
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43790
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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