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High Prevalence of Nonalcoholic Fatty Liver Disease Among Adolescents and Young Adults With Hypopituitarism due to Growth Hormone Deficiency

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Author(s)
Seok JinKangAhreum KwonMo Kyung JungHyun Wook ChaeSeung KimHong KohHyun Joo ShinHo-Seong Kim
Keimyung Author(s)
Kang, Seok Jin
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Endocr Pract
Issued Date
2021
Volume
27
Issue
11
Keyword
childhood-onsetgrowth hormone deficiencyhypopituitarismliver fibrosisnonalcoholic fatty liver disease
Abstract
Objective:
To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) in adolescents and young adults with hypopituitarism and to examine the associations of growth hormone (GH) deficiency with the occurrence of NAFLD.

Methods:
A cross-sectional study for the determination of NAFLD prevalence included 76 patients with childhood-onset hypopituitarism and 74 controls matched by age and body mass index (BMI). We investigated the prevalence of NAFLD in adolescent and young adult patients with hypopituitarism as well as the age- and BMI-matched controls. Among patients with hypopituitarism, anthropometric, clinical, and biochemical assessments using transient elastography and magnetic resonance imaging were performed. Logistic regression was used to identify the factors associated with NAFLD.

Results:
The adolescents and young adults with hypopituitarism exhibited higher prevalence of NAFLD than the age- and BMI-matched controls. Among patients with hypopituitarism, obesity and obesity-related metabolic derangements were significantly associated with liver steatosis and fibrosis, whereas lower insulin-like growth factor (IGF)-I standard deviation score (SDS) and IGF-I/IGF-binding protein 3 molar ratios were associated with steatosis. In regression analyses adjusted for BMI SDS, steatosis was found to be associated with a lower IGF-I SDS and IGF-I/IGF-binding protein 3 molar ratios, whereas liver fibrosis was found to be associated with a lower IGF-I SDS.

Conclusion:
Our results suggest that GH deficiency contributes to the occurrence of NAFLD, along with obesity and obesity-related metabolic changes. Because NAFLD occurs early in patients with hypopituitarism, the surveillance, weight control, and timely replacement of deficit hormones, including GH, are essential.
Keimyung Author(s)(Kor)
강석진
Publisher
School of Medicine (의과대학)
Citation
Seok JinKang et al. (2021). High Prevalence of Nonalcoholic Fatty Liver Disease Among Adolescents and Young Adults With Hypopituitarism due to Growth Hormone Deficiency. Endocr Pract, 27(11), 1149–1155. doi: 10.1016/j.eprac.2021.06.003
Type
Article
ISSN
1530-891X
Source
https://www.sciencedirect.com/science/article/abs/pii/S1530891X21010818
DOI
10.1016/j.eprac.2021.06.003
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43791
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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