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Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy

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Author(s)
Won-Kyu JangSu-Yeon LeeSunggyun ParkNam Hee RyooIlseon HwangJi Min ParkJin-Gon Bae
Keimyung Author(s)
Jang, Won KyuPark, Sung GyunRyoo, Nam HeeHwang, Il SeonBae, Jin Gon
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Pathology (병리학)
Journal Title
Int J Environ Res Public Health
Issued Date
2021
Volume
18
Issue
11
Keyword
COVID-19SARS-CoV-2vertical infection transmissionCOVID-19 antibodyneutralizing antibodyfirst trimester pregnancyplacentapathology
Abstract
There are reports that pregnant women infected with SARS-CoV-2 not only have increased morbidity but also increased complications and evidence of maternal and fetal vascular malperfusion on placental pathology. This was a retrospective study of pregnant women diagnosed with SARS-CoV-2 infection after March 2020. The results of reverse transcription polymerase chain reaction testing and IgM and IgG antibody testing of the amniotic fluid, cord blood, placenta, and maternal blood were confirmed at delivery. Placentas were evaluated histopathologically. The study included seven pregnant women diagnosed with SARS-CoV-2 infection during pregnancy at a mean gestational age of 14.5 weeks. Out of the seven women, five were infected during the first trimester. The mean gestational age at delivery was 38.4 weeks. The reverse transcription polymerase chain reaction results for maternal plasma, cord blood, placenta, and amniotic fluid were negative and IgG antibodies were detected in maternal plasma and cord blood. On placental pathology, maternal vascular malperfusion was found in only one case, fetal vascular malperfusion in four cases, and inflammatory changes were found in two cases. Pregnancy outcomes for women diagnosed with SARS-CoV-2 infection during early pregnancy are positive and it is likely that maternal antibodies are passed to the fetus, which results in a period of immunity.
Keimyung Author(s)(Kor)
장원규
박성균
류남희
황일선
배진곤
Publisher
School of Medicine (의과대학)
Citation
Won-Kyu Jang et al. (2021). Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy. Int J Environ Res Public Health, 18(11), 5709. doi: 10.3390/ijerph18115709
Type
Article
ISSN
1660-4601
Source
https://www.mdpi.com/1660-4601/18/11/5709
DOI
10.3390/ijerph18115709
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43802
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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