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Clinical Significance of Tumor Infiltrating Lymphocytes in Association with Hormone Receptor Expression Patterns in Epithelial Ovarian Cancer

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Author(s)
Gwan Hee HanIlseon HwangHanbyoul ChoKris YlayaJung-A ChoiHyunja KwonJoon-Yong ChungStephen M. HewittJae-Hoon Kim
Keimyung Author(s)
Hwang, Il Seon
Department
Dept. of Pathology (병리학)
Journal Title
Int J Mol Sci
Issued Date
2021
Volume
22
Issue
11
Keyword
epithelial ovarian cancerhormone receptorstriple dominant grouptumor infiltrating lymphocytesregulatory T cell
Abstract
Hormone receptor expression patterns often correlate with infiltration of specific lymphocytes in tumors. Specifically, the presence of specific tumor-infiltrating lymphocytes (TILs) with particular hormone receptor expression is reportedly associated with breast cancer, however, this has not been revealed in epithelial ovarian cancer (EOC). Therefore, we investigated the association between hormone receptor expression and TILs in EOC. Here we found that ERα, AR, and GR expression increased in EOC, while PR was significantly reduced and ERβ expression showed a reduced trend compared to normal epithelium. Cluster analysis indicated poor disease-free survival (DFS) in AR+/GR+/PR+ subgroup (triple dominant group); while the Cox proportional-hazards model highlighted the triple dominant group as an independent prognostic factor for DFS. In addition, significant upregulation of FoxP3+ TILs, PD-1, and PD-L1 was observed in the triple dominant group compared to other groups. NanoString analyses further suggested that tumor necrosis factor (TNF) and/or NF-κB signaling pathways were activated with significant upregulation of RELA, MAP3K5, TNFAIP3, BCL2L1, RIPK1, TRAF2, PARP1, and AKT1 in the triple dominant EOC group. The triple dominant subgroup correlates with poor prognosis in EOC. Moreover, the TNF and/or NF-κB signaling pathways may be responsible for hormone-mediated inhibition of the immune microenvironment.
Keimyung Author(s)(Kor)
황일선
Publisher
School of Medicine (의과대학)
Citation
Gwan Hee Han et al. (2021). Clinical Significance of Tumor Infiltrating Lymphocytes in Association with Hormone Receptor Expression Patterns in Epithelial Ovarian Cancer. Int J Mol Sci, 22(11), 5714. doi: 10.3390/ijms22115714
Type
Article
ISSN
1422-0067
Source
https://www.mdpi.com/1422-0067/22/11/5714
DOI
10.3390/ijms22115714
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43808
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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