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Comprehensive metabolomic profiling in early IgA nephropathy patients reveals urine glycine as a prognostic biomarker

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Author(s)
Sehoon ParkJueun LeeSeung Hee YangHajeong LeeJoo Young KimMinkyoung ParkKyu Hong KimJong Joo MoonSemin ChoSoojin LeeYaerim KimHajeong LeeJung Pyo LeeChang Wook JeongCheol KwakKwon Wook JooChun Soo LimYon Su KimGeum-Sook HwangDong Ki Kim
Keimyung Author(s)
Kim, Yae Rim
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Cell Mol Med
Issued Date
2021
Volume
25
Issue
11
Keyword
glomerulonephritisglycineIgA nephropathymetabolomicsprognosis
Abstract
Identification of a urinary metabolite biomarker with diagnostic or prognostic significance for early immunoglobulin A nephropathy (IgAN) is needed. We performed nuclear magnetic resonance-based metabolomic profiling and identified 26 metabolites in urine samples. We collected urine samples from 201, 77, 47, 36 and 136 patients with IgAN, patients with membranous nephropathy, patients with minimal change disease, patients with lupus nephritis and healthy controls, respectively. We determined whether a metabolite level is associated with the prognosis of IgAN through Cox regression and continuous net reclassification improvement (cNRI). Finally, in vitro experiments with human kidney tubular epithelial cells (hTECs) were performed for experimental validation. As the results, the urinary glycine level was higher in the IgAN group than the control groups. A higher urinary glycine level was associated with lower risk of eGFR 30% decline in IgAN patients. The addition of glycine to a predictive model including clinicopathologic information significantly improved the predictive power for the prognosis of IgAN [cNRI 0.72 (0.28-0.82)]. In hTECs, the addition of glycine ameliorated inflammatory signals induced by tumour necrosis factor-α. Our study demonstrates that urinary glycine may have diagnostic and prognostic value for IgAN and indicates that urinary glycine is a protective biomarker for IgAN.
Keimyung Author(s)(Kor)
김예림
Publisher
School of Medicine (의과대학)
Citation
Sehoon Park et al. (2021). Comprehensive metabolomic profiling in early IgA nephropathy patients reveals urine glycine as a prognostic biomarker. J Cell Mol Med, 25(11), 5177–5190. doi: 10.1111/jcmm.16520
Type
Article
ISSN
1582-4934
Source
https://onlinelibrary.wiley.com/doi/10.1111/jcmm.16520
DOI
10.1111/jcmm.16520
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43811
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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