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Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost

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Author(s)
Joon Mo KimSang Woo ParkMincheol SeongSeung Joo HaJi Woong LeeSeungsoo RhoChong Eun LeeKyoung Nam KimTae-Woo KimKyung Rim SungChan Yun Kim
Keimyung Author(s)
Lee, Chong Eun
Department
Dept. of Ophthalmology (안과학)
Journal Title
Pharmaceuticals (Basel)
Issued Date
2021
Volume
14
Issue
6
Keyword
ocular surface discomfortdry eyeglaucomaprostaglandin analoguelatanoprosttafluprostintraocular pressure
Abstract
In this study, we investigated the effect of preservative-free (PF) 0.0015% tafluprost (TA), to the preservative containing (PC) and the PF 0.005% latanoprost (LA) in Korean subjects. This study was conducted as a multi-center, randomized, investigator-blind, active controlled, parallel-group, clinical trial in adult patients (≥19 years) with open-angle glaucoma (OAG) and ocular hypertension (OHT). After a washout period, patients with an IOP between 15 and 35 mmHg were enrolled and evaluated the efficacy, safety, and compliance at 4, 8 and 12 weeks after the first administration. A total of 137 OAG and OHT patients were randomized. Statistically significant reductions in IOP were observed in all groups. Twelve weeks after each eye drop instillation, the mean IOP reduction was −4.59 ± 2.70 mmHg (−24.57 ± 13.49%) in the PC-LA group, −4.52 ± 2.17 mmHg (−24.41 ± 11.38%) in the PF-LA, and −3.14 ± 2.83 mmHg (−17.22 ± 14.57%) in the PF-TA group. The PF-LA showed significantly better responsiveness than did PF-TA. PF-LA was better tolerated than was PC-LA. There were no adverse events that led to cessation of eye drop use in any of the groups. In conclusion, IOP decreased similarly across the groups. PF-LA may provide a good choice for OAG patients with ocular surface diseases.
Keimyung Author(s)(Kor)
이종은
Publisher
School of Medicine (의과대학)
Citation
Joon Mo Kim et al. (2021). Comparison of the Safety and Efficacy between Preserved and Preservative-Free Latanoprost and Preservative-Free Tafluprost. Pharmaceuticals (Basel), 14(6), 501. doi: 10.3390/ph14060501
Type
Article
ISSN
1424-8247
Source
https://www.mdpi.com/1424-8247/14/6/501
DOI
10.3390/ph14060501
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43826
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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