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Prognostic value of metabolic parameters on (18)F-fluorodeoxyglucose positron tomography/computed tomography in classical rectal adenocarcinoma

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Affiliated Author(s)
배성욱정운경백성규송봉일원경숙김해원
Alternative Author(s)
Bae, Sung UkJeong, Woon KyungBaek, Seong KyuSong, Bong IlWon, Kyoung SookKim, Hae Won
Journal Title
Sci Rep
ISSN
2045-2322
Issued Date
2021
Abstract
We aimed to investigate the prognostic value of the metabolic parameters of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in classical rectal adenocarcinoma (CRAC). We retrospectively reviewed 149 patients with CRAC who underwent preoperative 18F-FDG PET/CT at initial diagnosis followed by curative surgical resection. 18F-FDG PET/CT metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) for disease-free survival (DFS) and overall survival (OS) were evaluated for prognostic significance by univariate and multivariate analyses, along with conventional risk factors including pathologic T (pT) stage, lymph node (LN) metastasis, lymphovascular invasion (LVI), perineural invasion (PNI), and preoperative carcinoembryonic antigen (CEA) level. On univariate analysis, high pT stage, positive LN metastasis, LVI, PNI, MTV, and TLG were significant prognostic factors affecting DFS (all P < 0.05), while CEA level, high pT stage, positive LN metastasis, LVI, PNI, MTV, and TLG affected OS (all P < 0.05). On multivariate analysis, positive LN metastasis, LVI, MTV, and TLG were independent prognostic factors affecting DFS (all P < 0.05), while CEA level, positive LN metastasis, and MTV affected OS (all P < 0.05). Thus, the volume-based metabolic parameters from preoperative 18F-FDG PET/CT scans are independent prognostic factors in patients with CRAC.
Department
Dept. of Surgery (외과학)
Dept. of Nuclear Medicine (핵의학)
Publisher
School of Medicine (의과대학)
Citation
Byung Wook Choi et al. (2021). Prognostic value of metabolic parameters on (18)F-fluorodeoxyglucose positron tomography/computed tomography in classical rectal adenocarcinoma. Sci Rep, 11, 12947. doi: 10.1038/s41598-021-92118-x
Type
Article
ISSN
2045-2322
DOI
10.1038/s41598-021-92118-x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43827
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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