계명대학교 의학도서관 Repository

Comparative effect of angiotensin converting enzyme inhibitor versus angiotensin ii type i receptor blocker in acute myocardial infarction with non-obstructive coronary arteries; from the Korea Acute Myocardial Infarction Registry - National Institute of Health

Metadata Downloads
Author(s)
Joon Ho AhnJu Yong HyunMyung Ho JeongJu Han KiYoung Joon HonDoo Sun SiMin Chul KimHun-Sik ParkDoo-Il KimSeung-Ho HurSeok Kyu OhYoungkeun Ahn
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cardiol J
Issued Date
2021
Volume
28
Issue
5
Keyword
non-obstructive coronary arteriesangiotensin converting enzyme inhibitorangiotensin II type I receptor blockerprognosis
Abstract
Background:
Selecting angiotensin converting enzyme inhibitor (ACEI) or angiotensin II type I receptor blocker (ARB) in patients diagnosed as acute myocardial infarction (AMI) with non-obstructive coronary arteries (MINOCA) is not established. The purpose of this study is to compare the clinical effect of ACEI vs. ARB in MINOCA patients.

Methods and results:
A total of 273 patients between November 2011 to June 2015, diagnosed with MINOCA who were registered in the Korea AMI Registry — National Institute of Health were enrolled. Patients were divided into ACEI (n = 112) and ARB groups (n = 161). The primary endpoint was cumulative incidence of major adverse cardiac events (MACE) defined as cardiac death, recurrent MI, any new revascularization during 2 years clinical follow-up. Secondary endpoint was heart failure requiring re-hospitalization. Propensity score matching analysis was done. The incidence of primary endpoint was similar (10.4% vs. 15.6%, HR: 0.65; 95% CI: 0.29–1.47; p = 0.301) among both groups. However, the incidence of recurrent MI was significantly lower in ACEI group compared to ARB group (2.1% vs. 10.4%, HR: 0.18, 95% CI: 0.04–0.86; p = 0.031).

Conclusions:
In the present study, the risk and incidence of MACE was similar between ACEI and ARB therapy in MINOCA patients. However, ACEI significantly reduced the risk of recurrent MI. Further larger scale multi-center randomized clinical trials are needed to clarify the proper use of renin angiotensin aldosterone system blocker in these patients.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Citation
Joon Ho Ahn et al. (2021). Comparative effect of angiotensin converting enzyme inhibitor versus angiotensin ii type i receptor blocker in acute myocardial infarction with non-obstructive coronary arteries; from the Korea Acute Myocardial Infarction Registry - National Institute of Health. Cardiol J, 28(5), 738–745. doi: 10.5603/CJ.a2020.0130
Type
Article
ISSN
1898-018X
Source
https://journals.viamedica.pl/cardiology_journal/article/view/68174
DOI
10.5603/CJ.a2020.0130
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43830
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.