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Apoptotic effect of jaceosidin on MCF-7 human breast cancer cells through modulation of ERK and p38 MAPK pathways

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Author(s)
Oyindamola Vivian Ojulari Jong-Beom Chae Seul Gi Lee Kyoungjin Min Taeg Kyu Kwon Ju-Ock Nam
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Nat Prod Res
Issued Date
2021
Volume
35
Issue
24
Keyword
MCF-7jaceosidinanticancer activityhuman breast cancer cellapoptosis
Abstract
Jaceosidin a flavone abundant in Artemisia species has been used for its beneficial effects. This study investigated the apoptotic effect of jaceosidin treatment on MCF-7 human breast cancer cells at varying concentrations of (0, 10, 20 and 40 µM) for 24 and 48 h treatment times. Jaceosidin treatment induced a significant (p < 0.05) dose-dependent increase in apoptosis of MCF-7 cells. Jaceosidin similarly modulated the expressions of apoptosis-associated proteins, and revealing a coaction between Bax and Bcl-2, striking a balance between cell survival/cell deaths. Besides, a significant increase in pro-apoptotic expression of cleaved PARP which is a key executioner in apoptosis was observed. Apoptosis was confirmed in the cells by flow cytometry which indicated an early apoptosis (7%, 17%), as well as late apoptosis (36%, 40%) of the cells in varying percentages as treatment concentration increased. Thus, this study demonstrates that jaceosidin could be used as a potential treatment for breast cancer.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine (의과대학)
Citation
Oyindamola Vivian Ojulari et al. (2021). Apoptotic effect of jaceosidin on MCF-7 human breast cancer cells through modulation of ERK and p38 MAPK pathways. Nat Prod Res, 35(24), 6049–6053. doi: 10.1080/14786419.2020.1817917
Type
Article
ISSN
1478-6427
Source
https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1817917
DOI
10.1080/14786419.2020.1817917
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43836
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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