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3D-printed, bioactive ceramic scaffold with rhBMP-2 in treating critical femoral bone defects in rabbits using the induced membrane technique

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Author(s)
Jae-Woo ChoBeom-Soo KimDo-Hyun YeoEic Ju LimSeungyeob SakongJunyoung LimSungNam ParkYong-Hoon JeongTae-Gon JungHyuk ChoiChang-Wug OhHak Jun KimJong Woong ParkJong-Keon Oh
Keimyung Author(s)
Kim, Beom Soo
Department
Dept. of Orthopedic Surgery (정형외과학)
Journal Title
J Orthop Res
Issued Date
2021
Volume
39
Issue
12
Keyword
3D printingbioactive ceramiccritical-sized bone defectrhBMP-2scaffold
Abstract
Although autogenous bone grafts are an optimal filling material for the induced membrane technique, limited availability and complications at the harvest site have created a need for alternative graft materials. We aimed to investigate the effect of an rhBMP-2-coated, 3D-printed, macro/microporous CaO–SiO2–P2O5–B2O3 bioactive ceramic scaffold in the treatment of critical femoral bone defects in rabbits using the induced membrane technique. A 15-mm segmental bone defect was made in the metadiaphyseal area of the distal femur of 14 rabbits. The defect was filled with polymethylmethacrylate cement and stabilized with a 2.0 mm locking plate. After the membrane matured for 4 weeks, the scaffold was implanted in two randomized groups: Group A (3D-printed bioceramic scaffold) and Group B (3D-printed, bioceramic scaffold with rhBMP-2). Eight weeks after implantation, the radiographic assessment showed that the healing rate of the defect was significantly higher in Group B (7/7, 100%) than in Group A (2/7, 29%). The mean volume of new bone formation around and inside the scaffold doubled in Group B compared to that in Group A. The mean static and dynamic stiffness were significantly higher in Group B. Histological examination revealed newly formed bone in both groups. Extensive cortical bone formation along the scaffold was found in Group B. Successful bone reconstruction in critical-sized bone defects could be obtained using rhBMP-2-coated, 3D-printed, macro/microporous bioactive ceramic scaffolds. This grafting material demonstrated potential as an alternative graft material in the induced membrane technique for reconstructing critical-sized bone defects.
Keimyung Author(s)(Kor)
김범수
Publisher
School of Medicine (의과대학)
Citation
Jae-Woo Cho et al. (2021). 3D-printed, bioactive ceramic scaffold with rhBMP-2 in treating critical femoral bone defects in rabbits using the induced membrane technique. J Orthop Res, 39(12), 2671–2680. doi: 10.1002/jor.25007
Type
Article
ISSN
1554-527X
Source
https://onlinelibrary.wiley.com/doi/10.1002/jor.25007
DOI
10.1002/jor.25007
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43840
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
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