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Viral load and rebound in children with coronavirus disease 2019 during the first outbreak in Daegu city

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Author(s)
Mi Ae ChuYoon Young JangDong Won LeeSung Hoon KimNamhee RyooSunggyun ParkJae Hee LeeHai Lee Chung
Keimyung Author(s)
Chu, Mi AeRyoo, Nam HeePark, Sung Gyun
Department
Dept. of Pediatrics (소아청소년학)
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
Clin Exp Pediatr
Issued Date
2021
Volume
64
Issue
12
Keyword
Child, COVID-19, SARS-CoV-2, Viral load
Abstract
Background:
Viral load and shedding duration are highly associated with the transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, limited studies have reported on viral load or shedding in children and adolescents infected with sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Purpose:
This study aimed to investigate the natural course of viral load in asymptomatic or mild pediatric cases.
Methods
Thirty-one children (<18 years) with confirmed SARS-CoV-2 infection were hospitalized and enrolled in this study. Viral loads were evaluated in nasopharyngeal swab samples using real-time reverse transcription polymerase chain reaction (E, RdRp, N genes). cycle threshold (Ct) values were measured when patients met the clinical criteria to be released from quarantine.

Results:
The mean age of the patients was 9.8 years, 18 (58%) had mild disease, and 13 (42%) were asymptomatic. Most children were infected by adult family members, most commonly by their mothers. The most common symptoms were fever and sputum (26%), followed by cough and runny nose. Nine patients (29%) had a high or intermediate viral load (Ct value≤30) when they had no clinical symptoms. Viral load showed no difference between symptomatic and asymptomatic patients. Viral rebounds were found in 15 cases (48%), which contributed to prolonged viral detection. The mean duration of viral detection was 25.6 days. Viral loads were significantly lower in patients with viral rebounds than in those with no rebound (E, P=0.003; RdRp, P=0.01; N, P=0.02).

Conclusion:
Our study showed that many pediatric patients with coronavirus disease 2019 (COVID-19) experienced viral rebound and showed viral detection for more than 3 weeks. Further studies are needed to investigate the relationship between viral rebound and infectiousness in COVID-19.
Keimyung Author(s)(Kor)
추미애
류남희
박성균
Publisher
School of Medicine (의과대학)
Citation
Mi Ae Chu et al. (2021). Viral load and rebound in children with coronavirus disease 2019 during the first outbreak in Daegu city. Clin Exp Pediatr, 64(12), 652–660. doi: 10.3345/cep.2020.02033
Type
Article
ISSN
2713-4148
Source
https://www.e-cep.org/journal/view.php?doi=10.3345/cep.2020.02033
DOI
10.3345/cep.2020.02033
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43849
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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