계명대학교 의학도서관 Repository

A multicenter study of interobserver variability in pathologic diagnosis of papillary breast lesions on core needle biopsy with WHO classification

Metadata Downloads
Author(s)
Hye Ju KangSun Young KwonAhrong KimWoo Gyeong KimEun Kyung KimAe Ree KimChungyeul KimSoo Kee MinSo Young ParkSun Hee SungHye Kyoung YoonAhwon LeeJi Shin LeeHyang Im LeeHo Chang LeeSung Chul LimSun Young JunMin Jung JungChang Won JungSoo Youn ChoEun Yoon ChoHye Jeong ChoiSo Yeon ParkJee Yeon KimIn Ae ParkYoungmee Kwon
Keimyung Author(s)
Kwon, Sun Young
Department
Dept. of Pathology (병리학)
Journal Title
J Pathol Transl Med
Issued Date
2021
Volume
55
Issue
6
Keyword
Papillary breast lesionCore needle biopsyInterobserver variabilityAgreement rate
Abstract
Background:
Papillary breast lesions (PBLs) comprise diverse entities from benign and atypical lesions to malignant tumors. Although PBLs are characterized by a papillary growth pattern, it is challenging to achieve high diagnostic accuracy and reproducibility. Thus, we investigated the diagnostic reproducibility of PBLs in core needle biopsy (CNB) specimens with World Health Organization (WHO) classification.

Methods:
Diagnostic reproducibility was assessed using interobserver variability (kappa value, κ) and agreement rate in the pathologic diagnosis of 60 PBL cases on CNB among 20 breast pathologists affiliated with 20 medical institutions in Korea. This analysis was performed using hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) staining for cytokeratin 5 (CK5) and p63. The pathologic diagnosis of PBLs was based on WHO classification, which was used to establish simple classifications (4-tier, 3-tier, and 2-tier).

Results:
On WHO classification, H&E staining exhibited 'fair agreement' (κ = 0.21) with a 47.0% agreement rate. Simple classifications presented improvement in interobserver variability and agreement rate. IHC staining increased the kappa value and agreement rate in all the classifications. Despite IHC staining, the encapsulated/solid papillary carcinoma (EPC/SPC) subgroup (κ = 0.16) exhibited lower agreement compared to the non-EPC/SPC subgroup (κ = 0.35) with WHO classification, which was similar to the results of any other classification systems.

Conclusions:
Although the use of IHC staining for CK5 and p63 increased the diagnostic agreement of PBLs in CNB specimens, WHO classification exhibited a higher discordance rate compared to any other classifications. Therefore, this result warrants further intensive consensus studies to improve the diagnostic reproducibility of PBLs with WHO classification.
Keimyung Author(s)(Kor)
권선영
Publisher
School of Medicine (의과대학)
Citation
Hye Ju Kang et al. (2021). A multicenter study of interobserver variability in pathologic diagnosis of papillary breast lesions on core needle biopsy with WHO classification. J Pathol Transl Med, 55(6), 380–387. doi: 10.4132/jptm.2021.07.29
Type
Article
ISSN
2383-7845
Source
https://www.jpatholtm.org/journal/view.php?number=16992
DOI
10.4132/jptm.2021.07.29
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43864
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.