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Electrocardiographic Manifestations in Patients with COVID-19: Daegu in South Korea

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Author(s)
Han-Joon BaeHyun Jun ChoChan-Hee LeeMyung Hwan BaeHyoung-Seob ParkByung Chun JungDong-Gu ShinYongkeun ChoJongmin HwangSeongwook HanKyu-Hwan ParkSe Yong JangYoung Soo Lee
Keimyung Author(s)
Park, Hyoung SeobHwang, Jong MinHan, Seong Wook
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Circ J
Issued Date
2021
Volume
51
Issue
10
Keyword
CoronavirusCOVID-19ECG
Abstract
Background and Objectives:
As the coronavirus disease 2019 (COVID-19) spreads worldwide, cardiac injury in patients infected with COVID-19 becomes a significant concern. Thus, this study investigates the impact of several electrocardiogram (ECG) parameters and disease severity in COVID-19 patients.

Methods:
Seven medical centers in Daegu admitted 822 patients with COVID-19 between February and April 2020. This study examined 267 patients among them who underwent an ECG test and evaluated their biochemical parameters like C-reactive protein (CRP), log N-terminal pro-B-type Natriuretic Peptide (NT-proBNP), cardiac enzyme, and ECG parameters (heart rate, PR interval, QRS interval, T inversion, QT interval, and Tpe [the interval between peak to end in a T wave]).

Results:
Those patients were divided into 3 groups of mild (100 patients), moderate (89 patients), and severe (78 patients) according to clinical severity score. The level of CRP, log NT-proBNP, and creatinine kinase-myocardial band were significantly increased in severe patients. Meanwhile, severe patients exhibited prolonged QT intervals (QTc) and Tpe (Tpe-c) compared to mild or moderate patients. Moreover, deceased patients (58; 21.7%) showed increased dispersion of QTc and Tpe-c compared with surviving patients (78.2±41.1 vs. 40.8±24.6 ms and 60.2±37.3 vs. 40.8±24.5 ms, both p<0.05, respectively). The QTc dispersion of more than 56.1 ms could predict the mortality in multivariate analysis (odd ratio, 11.55; 95% confidence interval, 3.746–42.306).

Conclusions:
COVID-19 infections could involve cardiac injuries, especially cardiac repolarization abnormalities. A prolonged QTc dispersion could be an independent predictable factor of mortality.
Keimyung Author(s)(Kor)
박형섭
황종민
한성욱
Publisher
School of Medicine (의과대학)
Citation
Han-Joon Bae et al. (2021). Electrocardiographic Manifestations in Patients with COVID-19: Daegu in South Korea. Korean Circ J, 51(10), 851–862. doi: 10.4070/kcj.2021.0116
Type
Article
ISSN
1738-5555
Source
https://pc.e-kcj.org/DOIx.php?id=10.4070/kcj.2021.0116
DOI
10.4070/kcj.2021.0116
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43868
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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