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Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report

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Author(s)
Terence KeeJong Cheol JeongHarun Ur-RashidNura Afza Salma BegumMel-Hatra ArakamaRomina DanguilanLkhaahuu Od-Erdene , Rosnawati YahyaYaerim KimHersharan Kaur SranBecky MaMaggie MaDevinder Singh RanaCurie AhnGhazali Ahmad
Keimyung Author(s)
Kim, Yae Rim
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean J Transplant
Issued Date
2021
Volume
35
Issue
4
Keyword
Kidney transplantationCOVID-19AsiaRegistry
Abstract
Background:
Asia is the global epicenter of the coronavirus disease 2019 (COVID-19) pandemic; however, COVID-19–related mortality in Asia remains lower than in other parts of the world. It is uncertain whether the mortality of COVID-19-infected kidney transplant recipients (KTXs) from Asia follows the lower mortality trends of the younger Asian population.

Methods:
Specific transplant centers from countries in the Asian Society of Transplantation were invited to participate in a study to examine the epidemiology, clinical features, natural history, and outcomes of COVID-19 infections in KTXs. Data were analyzed and compared with those of large cohort studies from other countries.

Results:
The study population was 87 KTXs from nine hospitals in seven Asian countries. Within the study population, 9% were aged 60 years and older, and 79% had at least one comorbidity. The majority of patients (69%) presented with mild-to-moderate COVID-19 severity. Disease progression was more frequently encountered among those with moderate or severe infection (23%) and non-survivors (55%). The mortality rate was 23% (n=20) and differed according to the level of care: 12% (n=1/8), 15% (n=10/67), and 100% (n=9/9) of patients managed as outpatients, in the general ward, and in the intensive care unit, respectively. Disease severity at the time of presentation was an independent predictor of mortality. Compared with the mortality rates in other studies worldwide, mortality rates in the current study were comparable.

Conclusions:
Mortality in Asian KTXs who were infected with COVID-19 remains high and could be related to comorbidity burden and the constraints of the general healthcare system when the COVID-19 caseload is high.
Keimyung Author(s)(Kor)
김예림
Publisher
School of Medicine (의과대학)
Citation
Terence Kee et al. (2021). Clinical characteristics, outcomes, and management of COVID-19 in kidney transplant recipients across Asia: an ASTREGO report. Korean J Transplant, 35(4), 218–229. doi: 10.4285/kjt.21.0024
Type
Article
ISSN
2671-8804
Source
https://www.ekjt.org/journal/view.html?uid=1461&vmd=Full
DOI
10.4285/kjt.21.0024
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43870
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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