계명대학교 의학도서관 Repository

Usefulness of cyclic thermal therapy and red blood cell scintigraphy in patients with chemotherapy-induced peripheral neuropathy

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Author(s)
Minjoo KimEun-Mi KimPhil-Sun OhSeok Tae LimMyung-Hee SohnEun-Kee SongKeon Uk ParkJin Young KimKyoung Sook WonHwan-Jeong Jeong
Keimyung Author(s)
Park, Keon UkKim, Jin YoungWon, Kyoung Sook
Department
Dept. of Internal Medicine (내과학)
Dept. of Nuclear Medicine (핵의학)
Journal Title
Korean J Pain
Issued Date
2021
Volume
34
Issue
4
Keyword
Antineoplastic AgentsBlood VolumeDrug-Related Side Effects and Adverse ReactionsDrug TherapyMicrocirculationNeuralgiaPeripheral Nervous System DiseasesPolyneuropathiesRadionuclide ImagingScintigraphySmall Fiber Neuropathy
Abstract
Background:
Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively. We hypothesized that cyclic thermal therapy would improve blood flow and microcirculation and improve the symptoms driven by CIPN.

Methods:
The criteria of assessment were blood volume in region of interest (ROI) in the images, and European Organization for Research and Treatment of Cancer–Quality of Life Questionnaire–Chemotherapy-Induced Peripheral Neuropathy 20 questionnaire scores. The blood volume was quantified by using red blood cell (RBC) scintigraphy. All patients were treated 10 times during 10 days. The thermal stimulations, between 15° and 41°, were repeatedly delivered to the patient's hands.

Results:
The total score of the questionnaires, the score of questions related to the upper limbs, the score of questions closely related to the upper limbs, and the score excluding the upper limbs questions was decreased. The blood volume was decreased, and the variance of blood volume was decreased. During cooling stimulation, the blood volume was decreased, and its variance was decreased. During warming stimulation, the blood volume was decreased, and its variance was decreased.

Conclusions:
We suggest that cyclic thermal therapy is useful to alleviate CIPN symptoms by blood circulation improvement. RBC scintigraphy can provide the quantitative information on blood volume under certain conditions such as stress, as well as rest, in peripheral tissue.
Keimyung Author(s)(Kor)
박건욱
김진영
원경숙
Publisher
School of Medicine (의과대학)
Citation
Minjoo Kim et al. (2021). Usefulness of cyclic thermal therapy and red blood cell scintigraphy in patients with chemotherapy-induced peripheral neuropathy. Korean J Pain, 34(4), 427–436. doi: 10.3344/kjp.2021.34.4.427
Type
Article
ISSN
2093-0569
Source
https://www.epain.org/journal/view.html?doi=10.3344/kjp.2021.34.4.427
DOI
10.3344/kjp.2021.34.4.427
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43876
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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