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J-shaped Relationship Between Chronic Kidney Disease and Serum Uric Acid Levels: A Cross-sectional Study on the Korean Population

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Author(s)
Bon San KooHye-Jin JeongChang-Nam SonSang-Hyon KimGheun-Ho KimJae-Bum Jun
Keimyung Author(s)
Jeong, Hye-JinSon, Chang NamKim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Rheum Dis
Issued Date
2021
Volume
28
Issue
4
Keyword
Chronic kidney diseasesHyperuricemiaUric acid
Abstract
Objective:
Both hypouricemia and hyperuricemia are reportedly associated with reduced kidney function. This study investigated the association between uric acid levels and the risk of reduced renal function in men and women.

Methods:
We conducted a cross-sectional study using data from a government-funded health examinee cohort of a Korean genome and epidemiological study. A total of 172,970 participants (58,981 men, 113,989 women) aged 40∼79 years were included. A logistic regression test was performed, and the odds ratio (OR) and 95% confidence interval (CI) were calculated to examine the relationship between stratified uric acid levels and the frequency of chronic kidney disease.

Results:
As the uric acid level increased, the risk of reduced renal function increased. Moreover, for uric acid levels ≤2.0 mg/dL, the risk of reduced renal function was higher than that of the reference group. Among the total, man, and woman groups, a statistically significant association was observed in men (OR 1.71, 95% CI 0.945∼3.111, OR 5.003, 95% CI 1.405∼17.809, and OR 1.377, 95% CI 0.696∼2.724, respectively).

Conclusion:
The OR of reduced renal function according to uric acid levels formed a J-shaped curve in both genders.
Keimyung Author(s)(Kor)
정혜진
손창남
김상현
Publisher
School of Medicine (의과대학)
Citation
Bon San Koo et al. (2021). J-shaped Relationship Between Chronic Kidney Disease and Serum Uric Acid Levels: A Cross-sectional Study on the Korean Population. J Rheum Dis, 28(4), 225–233. doi: 10.4078/jrd.2021.28.4.225
Type
Article
ISSN
2233-4718
Source
https://www.jrd.or.kr/journal/view.html?uid=1482&vmd=Full
DOI
10.4078/jrd.2021.28.4.225
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43881
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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